Sandbox Reserved 1779: Difference between revisions
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== Structure == | == Structure == | ||
=== Active and Inactive Form === | === Active and Inactive Form === | ||
[[Image: | [[Image:Finalmorphpic2.png|450 px|right|thumb|Figure 2: Inactive form of the thyrotropin receptor shown in blue (PDB: 7T9M). Active form of the thyrotropin receptor shown in green (PDB: 7T9I).]] | ||
The TSHR protein exists in dynamic equilibrium between two states: active and inactive (Figure 2) (GREEN LINK). TSH (GREEN LINK) will bind and keep the active state in the up position as a result of clashes between bound TSH and the cell membrane.<ref name="Faust" />. Glycosylations of an Asn52 residue cause this clash (GREEN LINK) on the <scene name='95/952707/Tsh_7t9i/1'>α-subunit of TSH</scene>. | The TSHR protein exists in dynamic equilibrium between two states: active and inactive (Figure 2) (GREEN LINK). TSH (GREEN LINK) will bind and keep the active state in the up position as a result of clashes between bound TSH and the cell membrane.<ref name="Faust" />. Glycosylations of an Asn52 residue cause this clash (GREEN LINK) on the <scene name='95/952707/Tsh_7t9i/1'>α-subunit of TSH</scene>. | ||
===Structural Overview=== | ===Structural Overview=== | ||
