Sandbox Reserved 1791: Difference between revisions
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== Antibodies == | == Antibodies == | ||
[https://my.clevelandclinic.org/health/body/22971-antibodies Antibodies] are an important part of the thyroid response. These proteins are made in an immune system response to get rid of unwanted antigens in the body. [https://www.btf-thyroid.org/thyroid-antibodies-explained Thyroid antibodies] are made when the body attacks the thyroid tissues. These antibodies are made to mimic [https://my.clevelandclinic.org/health/articles/23524-thyroid-stimulating-hormone-tsh-levels TSH (Thyroid Stimulating Hormone)]. TSH is released from the pituitary gland to bind to TSHR and stimulate the thyroid to make T3 and T4 hormones to regulate the metabolism. | [https://my.clevelandclinic.org/health/body/22971-antibodies Antibodies] are an important part of the thyroid response. These proteins are made in an immune system response to get rid of unwanted antigens in the body. [https://www.btf-thyroid.org/thyroid-antibodies-explained Thyroid antibodies] are made when the body attacks the thyroid tissues. These antibodies are made to mimic [https://my.clevelandclinic.org/health/articles/23524-thyroid-stimulating-hormone-tsh-levels TSH (Thyroid Stimulating Hormone)]. TSH is released from the pituitary gland to bind to TSHR and stimulate the thyroid to make T3 and T4 hormones to regulate the metabolism. These thyroid antibodies bind to the concave surface of the LRD. | ||
=== M22 === | === M22 === | ||
M22 is an activating antibody for TSHR. This antibody mimics TSH to activate the thyroid gland to produce T3 and T4 hormones. M22 makes | |||
The M22-TSHR complex contains a greater number of hydrogen bonds and salt bridges and fewer hydrophobic interactions than the TSH-TSHR complex, consistent with a higher M22 binding affinity. <ref name="M22"> DOI 10.1677/JME-08-0152</ref> | |||
=== K1 === | === K1 === | ||
[https://www.creativebiolabs.net/Anti-TSHR-Recombinant-Antibody-clone-K1-70-24911.htm K1] is an inhibitory antibody. | |||
== Active vs. Inactive State == | == Active vs. Inactive State == | ||
[[Image:Image-Inactive Inactive Proteopedia.png|300 px|right|thumb| Figure 2: An overview of the Inactive (red) vs Active (green) state of TSHR. PDB: 7WX5]] | [[Image:Image-Inactive Inactive Proteopedia.png|300 px|right|thumb| Figure 2: An overview of the Inactive (red) vs Active (green) state of TSHR. PDB: 7WX5]] | ||
