Sandbox Reserved 1789: Difference between revisions
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== Overall Structure == | == Overall Structure == | ||
=== SHOC2 === | === SHOC2 === | ||
<scene name='95/952717/Shoc2/1'>SHOC2</scene> | |||
<scene name='95/952717/Shoc2/1'>SHOC2</scene> is a scaffold protein composed of 20 leucine-rich repeat (LRR) domains that form a solenoid structure <ref name="Hauseman"/>. The leucine rich region forms a concave hydrophobic core which is necessary for binding with PP1C and MRAS. SHOC2 is the crucial mediator for SHOC2-PP1C-MRAS complex formation <ref name="Hauseman"/>. The leucine rich domain is very important in creating selectivity for the PP1C protein, as that protein is used for so many other complex pathways <ref name="Hauseman"/>. The LRR domains are stabilized by an N-terminal flanking 𝝰-helix and a C-terminal helix-turn-helix <ref name="Kwon">PMID:35831509</ref>. Alongside the conserved leucine residues in the LRR domain, there is a group of conserved asparagine residues that creates a stabilizing “asparagine ladder” that is necessary for the LRR fold, giving the SHOC2 its concave structure <ref name="Kwon" />. | |||
=== PP1C === | === PP1C === | ||
<scene name='95/952717/Pp1c/1'>PP1C</scene> | <scene name='95/952717/Pp1c/1'>PP1C</scene> | ||
