Sandbox Reserved 1771: Difference between revisions

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===Disease===

B-cells and their respective receptors play an important role in the immune response. Misregulation can lead to damaging consequences. [https://en.wikipedia.org/wiki/Autoimmune_disease Autoimmune diseases] develop when somatic cells are recognized as foreign antigens and the body tries to eliminate them <Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>. B-cell receptors are hypothesized to be an essential part of autoimmune disease development due to BCR function and role in the immune systems. In autoimmune diseases, BCRs improperly recognize somatic cells from different tissues and elicit the production of([https://en.wikipedia.org/wiki/Autoantibody autoantibodies])<Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>, causing the destruction of these cell types. Examples of these diseases include [https://en.wikipedia.org/wiki/Rheumatoid_arthritis rheumatoid arthritis] where the lining of joints is targeted and degraded, [https://en.wikipedia.org/wiki/Multiple_sclerosis multiple sclerosis] which targets the myelin sheath that surrounds nerve cells, [https://en.wikipedia.org/wiki/Type_1_diabetes type 1 diabetes mellitus] where the insulin producing cells are targeted for destruction, and [https://en.wikipedia.org/wiki/Lupus systematic lupus erythematosus] where multiple organ systems are targeted (skin, brain, lungs, and kidneys are common targets) <Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>.

B-cells and their respective receptors play an important role in the immune response. Misregulation can lead to damaging consequences. [https://en.wikipedia.org/wiki/Autoimmune_disease Autoimmune diseases] develop when somatic cells are recognized as foreign antigens and the body tries to eliminate them <Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>. B-cell receptors are hypothesized to be an essential part of autoimmune disease development due to BCR function and role in the immune systems. In autoimmune diseases, BCRs improperly recognize somatic cells from different tissues and elicit the production of [https://en.wikipedia.org/wiki/Autoantibody autoantibodies]<Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>, causing the destruction of these cell types. Examples of these diseases include [https://en.wikipedia.org/wiki/Rheumatoid_arthritis rheumatoid arthritis] where the lining of joints is targeted and degraded, [https://en.wikipedia.org/wiki/Multiple_sclerosis multiple sclerosis] which targets the myelin sheath that surrounds nerve cells, [https://en.wikipedia.org/wiki/Type_1_diabetes type 1 diabetes mellitus] where the insulin producing cells are targeted for destruction, and [https://en.wikipedia.org/wiki/Lupus systematic lupus erythematosus] where multiple organ systems are targeted (skin, brain, lungs, and kidneys are common targets) <Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>.

===Therapeutics===

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 ===Disease===
-B-cells and their respective receptors play an important role in the immune response. Misregulation can lead to damaging consequences. [https://en.wikipedia.org/wiki/Autoimmune_disease Autoimmune diseases] develop when somatic cells are recognized as foreign antigens and the body tries to eliminate them <Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>. B-cell receptors are hypothesized to be an essential part of autoimmune disease development due to BCR function and role in the immune systems. In autoimmune diseases, BCRs improperly recognize somatic cells from different tissues and elicit the production of([https://en.wikipedia.org/wiki/Autoantibody autoantibodies])<Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>, causing the destruction of these cell types. Examples of these diseases include [https://en.wikipedia.org/wiki/Rheumatoid_arthritis rheumatoid arthritis] where the lining of joints is targeted and degraded, [https://en.wikipedia.org/wiki/Multiple_sclerosis multiple sclerosis] which targets the myelin sheath that surrounds nerve cells, [https://en.wikipedia.org/wiki/Type_1_diabetes type 1 diabetes mellitus] where the insulin producing cells are targeted for destruction, and [https://en.wikipedia.org/wiki/Lupus systematic lupus erythematosus] where multiple organ systems are targeted (skin, brain, lungs, and kidneys are common targets) <Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>.
+B-cells and their respective receptors play an important role in the immune response. Misregulation can lead to damaging consequences. [https://en.wikipedia.org/wiki/Autoimmune_disease Autoimmune diseases] develop when somatic cells are recognized as foreign antigens and the body tries to eliminate them <Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>. B-cell receptors are hypothesized to be an essential part of autoimmune disease development due to BCR function and role in the immune systems. In autoimmune diseases, BCRs improperly recognize somatic cells from different tissues and elicit the production of [https://en.wikipedia.org/wiki/Autoantibody autoantibodies]<Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>, causing the destruction of these cell types. Examples of these diseases include [https://en.wikipedia.org/wiki/Rheumatoid_arthritis rheumatoid arthritis] where the lining of joints is targeted and degraded, [https://en.wikipedia.org/wiki/Multiple_sclerosis multiple sclerosis] which targets the myelin sheath that surrounds nerve cells, [https://en.wikipedia.org/wiki/Type_1_diabetes type 1 diabetes mellitus] where the insulin producing cells are targeted for destruction, and [https://en.wikipedia.org/wiki/Lupus systematic lupus erythematosus] where multiple organ systems are targeted (skin, brain, lungs, and kidneys are common targets) <Ref name="Yanaba K">Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284-99. doi: 10.1111/j.1600-065X.2008.00646.x. PMID: 18613843. </Ref>.
 ===Therapeutics===