Sandbox Reserved 1771: Difference between revisions

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===Therapeutics===

Current approaches to treatments of these autoimmune diseases include [https://en.wikipedia.org/wiki/Hormone_replacement_therapy replacement] and [https://en.wikipedia.org/wiki/Immunosuppression immunosuppressive] therapies <Ref name="Chandrashekara S">Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol. 2012 Nov-Dec;44(6):665-71. doi: 10.4103/0253-7613.103235. PMID: 23248391; PMCID: PMC3523489. </Ref>. Replacement therapy consists of the supplementation of important biological hormones (such as estrigen in Rheumatoid arthritis) or molecules (such as Vitamin D) that are reduced from disease. Immunosuppressive therapies instead treat disease symptoms to prevent further organ damage <Ref name="Chandrashekara S">Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol. 2012 Nov-Dec;44(6):665-71. doi: 10.4103/0253-7613.103235. PMID: 23248391; PMCID: PMC3523489. </Ref>. Immunosuppressive therapies include drugs that suppress the immune system response as well as [https://en.wikipedia.org/wiki/Anti-inflammatory anti-inflammatory] drugs. [https://en.wikipedia.org/wiki/Gene_therapy Gene therapy] has also been studied as another therapeutic avenue. In gene therapy, cells express specific genes for the regulation of proinflammatory molecules or reduction of immune cells to the site of disease <Ref name="Shu SA">Shu SA, Wang J, Tao MH, Leung PS. Gene Therapy for Autoimmune Disease. Clin Rev Allergy Immunol. 2015 Oct;49(2):163-76. doi: 10.1007/s12016-014-8451-x. PMID: 25277817. </Ref>. Currently, the majority of treatments for autoimmune diseases aim to improve the quality of life and reduce symptoms as there has not yet been an established cure.

Current approaches to treatments of these autoimmune diseases include [https://en.wikipedia.org/wiki/Hormone_replacement_therapy replacement] and [https://en.wikipedia.org/wiki/Immunosuppression immunosuppressive] therapies <Ref name="Chandrashekara S">Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol. 2012 Nov-Dec;44(6):665-71. doi: 10.4103/0253-7613.103235. PMID: 23248391; PMCID: PMC3523489. </Ref>. Replacement therapy consists of the supplementation of important biological hormones (such as estrigen in Rheumatoid arthritis) or molecules (such as Vitamin D <Ref name="Dupuis M"> Dupuis, M.L., Pagano, M.T., Pierdominici, M. et al. The role of vitamin D in autoimmune diseases: could sex make the difference?. Biol Sex Differ 12, 12 (2021). https://doi.org/10.1186/s13293-021-00358-3. </Ref>) that are reduced from disease. Immunosuppressive therapies instead treat disease symptoms to prevent further organ damage <Ref name="Chandrashekara S">Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol. 2012 Nov-Dec;44(6):665-71. doi: 10.4103/0253-7613.103235. PMID: 23248391; PMCID: PMC3523489. </Ref>. Immunosuppressive therapies include drugs that suppress the immune system response as well as [https://en.wikipedia.org/wiki/Anti-inflammatory anti-inflammatory] drugs. [https://en.wikipedia.org/wiki/Gene_therapy Gene therapy] has also been studied as another therapeutic avenue. In gene therapy, cells express specific genes for the regulation of proinflammatory molecules or reduction of immune cells to the site of disease <Ref name="Shu SA">Shu SA, Wang J, Tao MH, Leung PS. Gene Therapy for Autoimmune Disease. Clin Rev Allergy Immunol. 2015 Oct;49(2):163-76. doi: 10.1007/s12016-014-8451-x. PMID: 25277817. </Ref>. Currently, the majority of treatments for autoimmune diseases aim to improve the quality of life and reduce symptoms as there has not yet been an established cure.

==3D structures of the BCR==

Sandbox Reserved 1771: Difference between revisions

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 ===Therapeutics===
-Current approaches to treatments of these autoimmune diseases include [https://en.wikipedia.org/wiki/Hormone_replacement_therapy replacement] and [https://en.wikipedia.org/wiki/Immunosuppression immunosuppressive] therapies <Ref name="Chandrashekara S">Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol. 2012 Nov-Dec;44(6):665-71. doi: 10.4103/0253-7613.103235. PMID: 23248391; PMCID: PMC3523489. </Ref>. Replacement therapy consists of the supplementation of important biological hormones (such as estrigen in Rheumatoid arthritis) or molecules (such as Vitamin D) that are reduced from disease. Immunosuppressive therapies instead treat disease symptoms to prevent further organ damage <Ref name="Chandrashekara S">Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol. 2012 Nov-Dec;44(6):665-71. doi: 10.4103/0253-7613.103235. PMID: 23248391; PMCID: PMC3523489. </Ref>. Immunosuppressive therapies include drugs that suppress the immune system response as well as [https://en.wikipedia.org/wiki/Anti-inflammatory anti-inflammatory] drugs. [https://en.wikipedia.org/wiki/Gene_therapy Gene therapy] has also been studied as another therapeutic avenue. In gene therapy, cells express specific genes for the regulation of proinflammatory molecules or reduction of immune cells to the site of disease <Ref name="Shu SA">Shu SA, Wang J, Tao MH, Leung PS. Gene Therapy for Autoimmune Disease. Clin Rev Allergy Immunol. 2015 Oct;49(2):163-76. doi: 10.1007/s12016-014-8451-x. PMID: 25277817. </Ref>. Currently, the majority of treatments for autoimmune diseases aim to improve the quality of life and reduce symptoms as there has not yet been an established cure.
+Current approaches to treatments of these autoimmune diseases include [https://en.wikipedia.org/wiki/Hormone_replacement_therapy replacement] and [https://en.wikipedia.org/wiki/Immunosuppression immunosuppressive] therapies <Ref name="Chandrashekara S">Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol. 2012 Nov-Dec;44(6):665-71. doi: 10.4103/0253-7613.103235. PMID: 23248391; PMCID: PMC3523489. </Ref>. Replacement therapy consists of the supplementation of important biological hormones (such as estrigen in Rheumatoid arthritis) or molecules (such as Vitamin D <Ref name="Dupuis M"> Dupuis, M.L., Pagano, M.T., Pierdominici, M. et al. The role of vitamin D in autoimmune diseases: could sex make the difference?. Biol Sex Differ 12, 12 (2021). https://doi.org/10.1186/s13293-021-00358-3. </Ref>) that are reduced from disease. Immunosuppressive therapies instead treat disease symptoms to prevent further organ damage <Ref name="Chandrashekara S">Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol. 2012 Nov-Dec;44(6):665-71. doi: 10.4103/0253-7613.103235. PMID: 23248391; PMCID: PMC3523489. </Ref>. Immunosuppressive therapies include drugs that suppress the immune system response as well as [https://en.wikipedia.org/wiki/Anti-inflammatory anti-inflammatory] drugs. [https://en.wikipedia.org/wiki/Gene_therapy Gene therapy] has also been studied as another therapeutic avenue. In gene therapy, cells express specific genes for the regulation of proinflammatory molecules or reduction of immune cells to the site of disease <Ref name="Shu SA">Shu SA, Wang J, Tao MH, Leung PS. Gene Therapy for Autoimmune Disease. Clin Rev Allergy Immunol. 2015 Oct;49(2):163-76. doi: 10.1007/s12016-014-8451-x. PMID: 25277817. </Ref>. Currently, the majority of treatments for autoimmune diseases aim to improve the quality of life and reduce symptoms as there has not yet been an established cure.
 ==3D structures of the BCR==