Sandbox Reserved 1777: Difference between revisions
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==MRAS== | ==MRAS== | ||
<scene name='95/952705/Mras_structure/4'>MRAS</scene> is a monomeric GTPase and is anchored in the cell membrane. When MRAS binds GTP, it becomes active and can only bind the complex once activated <ref name="Hauseman" />. MRAS is a subvariant of the RAS protein and therefore shares most of its regulatory and effector interactions<Ref name= 'Young'>Young, L., Rodriguez-Viciana, P. MRAS: A Close but Understudied Member of the RAS Family. Cold Spring Harbor Perspectives in Medicine (2018). doi: 10.1101/cshperspect.a033621. [https://perspectivesinmedicine.cshlp.org/content/8/12/a033621.full.pdf+html. DOI: 0.1101/cshperspect.a033621]. </Ref>. '''While other RAS variants bind in complex with SHOC2 and PP1 to allow it to have phosphatase activity, MRAS binds the tightest.''' | <scene name='95/952705/Mras_structure/4'>MRAS</scene> is a monomeric GTPase and is anchored in the cell membrane by a C-terminal S-Farnesyl cysteine carboxylmethyl ester. When MRAS binds GTP, it becomes active and can only bind the complex once activated <ref name="Hauseman" />. MRAS is a subvariant of the RAS protein and therefore shares most of its regulatory and effector interactions<Ref name= 'Young'>Young, L., Rodriguez-Viciana, P. MRAS: A Close but Understudied Member of the RAS Family. Cold Spring Harbor Perspectives in Medicine (2018). doi: 10.1101/cshperspect.a033621. [https://perspectivesinmedicine.cshlp.org/content/8/12/a033621.full.pdf+html. DOI: 0.1101/cshperspect.a033621]. </Ref>. '''While other RAS variants bind in complex with SHOC2 and PP1 to allow it to have phosphatase activity, MRAS binds the tightest.''' | ||
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