Sandbox Reserved 1794: Difference between revisions
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NTCP exists in two different conformations; the <scene name='95/952722/Open_pore_conf/4'>open pore conformation</scene> and the <scene name='95/952722/Inward_facing_conf/1'>inward facing conformation</scene>. <ref name="Goutam"/> To transport bile salts across the plasma membrane of hepocytes, NTCP undergoes a conformational change from inward facing to open pore. In this movement, the core and panel | NTCP exists in two different conformations; the <scene name='95/952722/Open_pore_conf/4'>open pore conformation</scene> and the <scene name='95/952722/Inward_facing_conf/1'>inward facing conformation</scene>. <ref name="Goutam"/> To transport bile salts across the plasma membrane of hepocytes, NTCP undergoes a conformational change from inward facing to open pore. In this movement, the <scene name='95/952722/Ntcp_core_domain-_blue/8'>core domain</scene> and the <scene name='95/952722/Ntcp_panel_domain-_red/4'>panel domain</scene> rotate 20° with the <font color='red'><b>panel domain</b></font> moving 5 Å away from the <font color='#6060ff'><b>core domain</b></font>, which remains relatively rigid. This conformational change reveals the two sodium ion binding sites as well as the amphipathic pore in the membrane. The movement of the panel domain is facilitated by <scene name='95/952722/Pro_and_gly_hinges/5'>proline and glycine residues</scene> located in the connector helices between the panel and core domains. <scene name='95/952722/Pro_and_gly_hinges/7'>These residues</scene> <font color='#FCE205'><b>(yellow)</b></font> act as hinges that assist in the movement of the panel domain away from the core domain. <ref name="Goutam"/> | ||
== Bile Salt Transport == | == Bile Salt Transport == | ||
