Sandbox Reserved 1771: Difference between revisions
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[[Image: FINAL1.PNG| 500 px|thumb | right| '''Figure 2.''' Diagram of B-cell formation, subsequent divergence, and attack of somatic cells seen in autoimmune diseases. All cell types are labeled and BCRs are shown in red, while antigens are shown in blue. When a defective BCR recognizes a somatic cell instead of a foreign pathogen, an immune response occurs, leading to degradation of tissue and disease.]] | [[Image: FINAL1.PNG| 500 px|thumb | right| '''Figure 2.''' Diagram of B-cell formation, subsequent divergence, and attack of somatic cells seen in autoimmune diseases. All cell types are labeled and BCRs are shown in red, while antigens are shown in blue. When a defective BCR recognizes a somatic cell instead of a foreign pathogen, an immune response occurs, leading to degradation of tissue and disease.]] | ||
The formation of B-cells occurs in the bone marrow from hematopoietic stem cells<ref name="Althwaiqeb">Althwaiqeb, S. ''Histology, B Cell Lymphocyte''; StatPearls Publishing, 2023. </ref>. Once formed, B-cell receptors are attached to B-cells through the aid of membrane-bound proteins in bone marrow cells. During this process, gene recombination occurs, which allows unique BCRs to become highly specific to different antigens<ref name="Althwaiqeb">Althwaiqeb, S. ''Histology, B Cell Lymphocyte''; StatPearls Publishing, 2023. </ref>. Once they are formed, [https://en.wikipedia.org/wiki/B_cell B-cells diverge] and become either memory cells or plasma cells. Memory cells still have BCRs and initiate a faster immune response, while plasma cells secrete antibodies | The formation of B-cells occurs in the bone marrow from hematopoietic stem cells<ref name="Althwaiqeb">Althwaiqeb, S. ''Histology, B Cell Lymphocyte''; StatPearls Publishing, 2023. </ref>. Once formed, B-cell receptors are attached to B-cells through the aid of membrane-bound proteins in bone marrow cells. During this process, gene recombination occurs, which allows unique BCRs to become highly specific to different antigens<ref name="Althwaiqeb">Althwaiqeb, S. ''Histology, B Cell Lymphocyte''; StatPearls Publishing, 2023. </ref>. Once they are formed, [https://en.wikipedia.org/wiki/B_cell B-cells diverge] and become either memory cells or plasma cells <ref name="Wang Y">Wang Y, Liu J, Burrows PD, Wang JY. B Cell Development and Maturation. Adv Exp Med Biol. 2020;1254:1-22. doi: 10.1007/978-981-15-3532-1_1. PMID: 32323265.</ref>. Memory cells still have BCRs and initiate a faster immune response during a secondary infection, while plasma cells secrete antibodies for immediate response to foreign antigens <ref name="Althwaiqeb">Althwaiqeb, S. ''Histology, B Cell Lymphocyte''; StatPearls Publishing, 2023. </ref>. | ||
===Disease=== | ===Disease=== | ||
