Sandbox Reserved 1790: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Inaya Patel (talk | contribs) No edit summary |
Inaya Patel (talk | contribs) No edit summary |
||
| Line 28: | Line 28: | ||
==PP1C and MRAS== | ==PP1C and MRAS== | ||
The interactions between <scene name='95/ | The interactions between <scene name='95/952718/Mras_and_pp1c/1'>PP1C and MRAS</scene> are mediated by four main <scene name='95/952716/Mras_and_pp1c/3'>hydrogen bonds</scene>: R188-D48, M190-Q35, D197-H53, Q198-K36. It is unclear whether PP1C must bind to SHOC2 before MRAS binds or if PP1C and MRAS can bind to SHOC2 at the same time <ref name="Lavoie" />. | ||
=Signaling Pathway= | =Signaling Pathway= | ||
The SMP signaling pathway begins with the formation of the SMP complex. Initially, a ligand must bind to a receptor tyrosine kinase. This signals SHOC2 to bind to PP1C forming a binary complex that then binds to the membrane bound MRAS. Some literature indicates that the three proteins bind at the same time but the order is largely unknown. Figure 2 shows the proteins binding one at a time. Once the SMP complex forms, its target is the NTpS also known as S259. The serine is directly dephosphorylated by PP1C by SHOC2 and MRAS increase its specificity for S259. | The SMP signaling pathway begins with the formation of the SMP complex. Initially, a ligand must bind to a receptor tyrosine kinase. This signals SHOC2 to bind to PP1C forming a binary complex that then binds to the membrane bound MRAS. Some literature indicates that the three proteins bind at the same time but the order is largely unknown. Figure 2 shows the proteins binding one at a time. Once the SMP complex forms, its target is the NTpS also known as S259. The serine is directly dephosphorylated by PP1C by SHOC2 and MRAS increase its specificity for S259. | ||
