8ebt: Difference between revisions

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'''Unreleased structure'''


The entry 8ebt is ON HOLD
==XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5)==
 
<StructureSection load='8ebt' size='340' side='right'caption='[[8ebt]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
Authors: Kim, J., Yang, W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ebt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EBT FirstGlance]. <br>
Description: XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=VM6:3-[(2E)-2-{(3Z,5E)-5-[1-(3-hydroxypropyl)-3,3-dimethyl-1,3-dihydro-2H-indol-2-ylidene]pent-3-en-1-ylidene}-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]propyl+dihydrogen+phosphite'>VM6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ebt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ebt OCA], [https://pdbe.org/8ebt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ebt RCSB], [https://www.ebi.ac.uk/pdbsum/8ebt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ebt ProSAT]</span></td></tr>
[[Category: Kim, J]]
</table>
[[Category: Yang, W]]
== Function ==
[https://www.uniprot.org/uniprot/TF2H2_HUMAN TF2H2_HUMAN] Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Kim J]]
[[Category: Yang W]]
Retrieved from "https://proteopedia.org/8ebt"