Sandbox Reserved 1790: Difference between revisions

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==SHOC2 and MRAS==

MRAS is initially bound to GDP causing it to be in its inactive state. Inactive GDP-MRAS cannot bind to the SHOC2-PP1C complex due to steric clashing. Once GDP is exchanged for GTP when signaled by growth factors to activate the protein, conformational changes occur within the switch I and switch II regions to allow <scene name='95/952716/Scho2-mras-interactions/2'>MRAS to interact with SHOC2</scene>. These <scene name='95/952716/Scho2-mras-interactions/1'>interactions</scene> include hydrogen bonds, ionic interactions, and π stacking. The primary hydrogen bonds are R288-Q71 and R177-E47. Pi staking occurs at R104-R83 <ref name="Lavoie">Lavoie H, Therrien M. Structural keys unlock RAS-MAPK cellular signaling pathway. Nature. 2022 Sep;609(7926):248-249. [http://dx.doi.org/10.1038/d41586-022-02189-7 doi: 10.1038/d41586-022-02189-7. PMID: 35970881.]</ref>.

MRAS is initially bound to GDP causing it to be in its inactive state. Inactive GDP-MRAS cannot bind to the SHOC2-PP1C complex due to steric clashing. Once GDP is exchanged for GTP when signaled by growth factors to activate the protein, conformational changes occur within the switch I and switch II regions to allow <scene name='95/952716/Scho2-mras-interactions/2'>MRAS to interact with SHOC2</scene>. These <scene name='95/952716/Scho2-mras-interactions/1'>interactions</scene> include hydrogen bonds, ionic interactions, and π stacking. The primary hydrogen bonds are R288-Q71 and R177-E47. π staking occurs at R104-R83 <ref name="Lavoie">Lavoie H, Therrien M. Structural keys unlock RAS-MAPK cellular signaling pathway. Nature. 2022 Sep;609(7926):248-249. [http://dx.doi.org/10.1038/d41586-022-02189-7 doi: 10.1038/d41586-022-02189-7. PMID: 35970881.]</ref>.

==PP1C and MRAS==

Sandbox Reserved 1790: Difference between revisions

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 ==SHOC2 and MRAS==
-MRAS is initially bound to GDP causing it to be in its inactive state. Inactive GDP-MRAS cannot bind to the SHOC2-PP1C complex due to steric clashing. Once GDP is exchanged for GTP when signaled by growth factors to activate the protein, conformational changes occur within the switch I and switch II regions to allow <scene name='95/952716/Scho2-mras-interactions/2'>MRAS to interact with SHOC2</scene>. These <scene name='95/952716/Scho2-mras-interactions/1'>interactions</scene> include hydrogen bonds, ionic interactions, and π stacking. The primary hydrogen bonds are R288-Q71 and R177-E47. Pi staking occurs at R104-R83 <ref name="Lavoie">Lavoie H, Therrien M. Structural keys unlock RAS-MAPK cellular signaling pathway. Nature. 2022 Sep;609(7926):248-249. [http://dx.doi.org/10.1038/d41586-022-02189-7 doi: 10.1038/d41586-022-02189-7. PMID: 35970881.]</ref>.
+MRAS is initially bound to GDP causing it to be in its inactive state. Inactive GDP-MRAS cannot bind to the SHOC2-PP1C complex due to steric clashing. Once GDP is exchanged for GTP when signaled by growth factors to activate the protein, conformational changes occur within the switch I and switch II regions to allow <scene name='95/952716/Scho2-mras-interactions/2'>MRAS to interact with SHOC2</scene>. These <scene name='95/952716/Scho2-mras-interactions/1'>interactions</scene> include hydrogen bonds, ionic interactions, and π stacking. The primary hydrogen bonds are R288-Q71 and R177-E47. π staking occurs at R104-R83 <ref name="Lavoie">Lavoie H, Therrien M. Structural keys unlock RAS-MAPK cellular signaling pathway. Nature. 2022 Sep;609(7926):248-249. [http://dx.doi.org/10.1038/d41586-022-02189-7 doi: 10.1038/d41586-022-02189-7. PMID: 35970881.]</ref>.
 ==PP1C and MRAS==