Sandbox Reserved 1792: Difference between revisions

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== Active vs Inactive State==

[[~~Image:~~Image:Untitled (1).jpg|300 px|right|thumb| Figure 2: An overview of the Inactive (pink) vs Active (green) state of TSHR. PDB: 7t9m and 7t9i]] [[Image:Inactive v active residue.png|300 px|right|thumb| Figure 3: A zoomed in view of the Y279 residue in the Hinge Region of TSHR, showing the 6 angstrom move of Y279 during the activation of TSHR. Active TSHR is shown in green (PDB: 7t9i) and inactive TSHR is shown in pink (PDB: 7t9m).]]

[[Image:Untitled (1).jpg|300 px|right|thumb| Figure 2: An overview of the Inactive (pink) vs Active (green) state of TSHR. PDB: 7t9m and 7t9i]] [[Image:Inactive v active residue.png|300 px|right|thumb| Figure 3: A zoomed in view of the Y279 residue in the Hinge Region of TSHR, showing the 6 angstrom move of Y279 during the activation of TSHR. Active TSHR is shown in green (PDB: 7t9i) and inactive TSHR is shown in pink (PDB: 7t9m).]]

When TSHR is not bound to TSH, it is in the <scene name='95/952720/Inactivetshr/8'>inactive state</scene>. This is also considered the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashing between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/6'>active or "up" state</scene> (fig 2). During this transition, the Extracellular domains rotate 55° along an axis. This rotation is caused by conformational changes within the <scene name='95/952720/Hinge_region_spin/1'>Hinge Region</scene>, specifically at the <scene name='95/952720/Hinge_region_residues/2'>Y279 residue</scene>. This residue moves 6 angstroms relative to I486, which is a residue located in the Transmembrane Region <ref name="Faust"/> (Fig 3).

== Specific Residues ==

Sandbox Reserved 1792: Difference between revisions

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@@ Line 23: / Line 23: @@
 == Active vs Inactive State==
-[[Image:Image:Untitled (1).jpg|300 px|right|thumb| Figure 2: An overview of the Inactive (pink) vs Active (green) state of TSHR. PDB: 7t9m and 7t9i]] [[Image:Inactive v active residue.png|300 px|right|thumb| Figure 3: A zoomed in view of the Y279 residue in the Hinge Region of TSHR, showing the 6 angstrom move of Y279 during the activation of TSHR. Active TSHR is shown in green (PDB: 7t9i) and inactive TSHR is shown in pink (PDB: 7t9m).]]
+[[Image:Untitled (1).jpg|300 px|right|thumb| Figure 2: An overview of the Inactive (pink) vs Active (green) state of TSHR. PDB: 7t9m and 7t9i]] [[Image:Inactive v active residue.png|300 px|right|thumb| Figure 3: A zoomed in view of the Y279 residue in the Hinge Region of TSHR, showing the 6 angstrom move of Y279 during the activation of TSHR. Active TSHR is shown in green (PDB: 7t9i) and inactive TSHR is shown in pink (PDB: 7t9m).]]
 When TSHR is not bound to TSH, it is in the <scene name='95/952720/Inactivetshr/8'>inactive state</scene>. This is also considered the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashing between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/6'>active or "up" state</scene> (fig 2). During this transition, the Extracellular domains rotate 55° along an axis. This rotation is caused by conformational changes within the <scene name='95/952720/Hinge_region_spin/1'>Hinge Region</scene>, specifically at the <scene name='95/952720/Hinge_region_residues/2'>Y279 residue</scene>. This residue moves 6 angstroms relative to I486, which is a residue located in the Transmembrane Region <ref name="Faust"/> (Fig 3).
 == Specific Residues ==