Sandbox Reserved 1785: Difference between revisions
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Within the transmembrane region, '''{{Font color|violet|heavy chain A}}''' and <b><span class="text-blue">heavy chain B</span></b> associate (Figure 1) asymmetrically to facilitate intracellular signaling cascades. The transmembrane heavy chain interface allows them to pack together via [https://en.wikipedia.org/wiki/Van_der_Waals_force Van der Waals] contacts, but there are also prominent <scene name='95/952713/Trans_heavy/ | Within the transmembrane region, '''{{Font color|violet|heavy chain A}}''' and <b><span class="text-blue">heavy chain B</span></b> associate (Figure 1) asymmetrically to facilitate intracellular signaling cascades. The transmembrane heavy chain interface allows them to pack together via [https://en.wikipedia.org/wiki/Van_der_Waals_force Van der Waals] contacts, but there are also prominent <scene name='95/952713/Trans_heavy/11'>hydrogen bonds</scene> between each chain. More specifically, the hydroxyl group from Ser584 on '''{{Font color|violet|heavy chain A}}''' donates a hydrogen bond to Ser584 and to Ser588 on <b><span class="text-blue">heavy chain B</span></b>. This creates a [https://en.wikipedia.org/wiki/Hydrogen_bond bifurcated hydrogen bond], essentially forming a “fork” between the two chains to help stabilize them and maintain the transmission of the signal once the cell is activated. Because transmembrane Ig molecules cannot efficiently initiate the signal cascade, they must associate with the <b><span class="text-brown">Igα</span></b> and <b><span class="text-orange">Igβ</span></b> chains within the BCR. <ref name="Su">PMID:35981043</ref> | ||
Furthermore, both the <b><span class="text-brown">Igα</span></b> and <b><span class="text-orange">Igβ</span></b> chains have cytoplasmic tails that extend into the B cell (Figure 1). Each of these tails contain an [https://en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_activation_motif ITAM region] to facilitate signal transduction (Figure 4). <ref name="Ma">PMID:35981028</ref> | Furthermore, both the <b><span class="text-brown">Igα</span></b> and <b><span class="text-orange">Igβ</span></b> chains have cytoplasmic tails that extend into the B cell (Figure 1). Each of these tails contain an [https://en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_activation_motif ITAM region] to facilitate signal transduction (Figure 4). <ref name="Ma">PMID:35981028</ref> | ||
