Sandbox Reserved 1785: Difference between revisions

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===Fab Region===

The Fab region of the antibody is where antigen recognition occurs upon binding (Figure 1). On each arm is one heavy ('''{{Font color|violet|A}}'''/B) and one light (A/B) chain, both containing domains identical to their respective counterparts. Repeats of β-sandwiches form the [https://en.wikipedia.org/wiki/Antibody constant and variable domains] within the Fab region as antigen recognition occurs at the variable domain while the constant domain connects it to the rest of the IgM complex. Because the Fab region of IgM is poorly resolved, a structural analysis of an HIV neutralizing antibody called VCR01 was performed to approximate where an antigen would bind to at the <scene name='95/952714/Variable_region/1'>variable region</scene>. <ref name="Zhou">PMID:20616231</ref>

The <scene name='95/952713/Fab_region/1'>Fab region</scene> of the antibody is where antigen recognition occurs upon binding (Figure 1). On each arm is one heavy ('''{{Font color|violet|A}}'''/B) and one light (A/B) chain, both containing domains identical to their respective counterparts. Repeats of β-sandwiches form the [https://en.wikipedia.org/wiki/Antibody constant and variable domains] within the Fab region as antigen recognition occurs at the variable domain while the constant domain connects it to the rest of the IgM complex. Because the Fab region of IgM is poorly resolved, a structural analysis of an HIV neutralizing antibody called VCR01 was performed to approximate where an antigen would bind to at the <scene name='95/952714/Variable_region/1'>variable region</scene>. <ref name="Zhou">PMID:20616231</ref>

The IgM-BCR contains areas referred to as [https://en.wikipedia.org/wiki/Complementarity-determining_region complementary-determining regions](CDRs), which are where the antigen makes <scene name='95/952713/Antigen_antibody_contact/4'>contact</scene> with the antibody on the Fab domain. Figure 2 depicts this as a surface representation given that the specific residues within the antigen-binding motif are unknown.

Sandbox Reserved 1785: Difference between revisions

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@@ Line 40: / Line 40: @@
 ===Fab Region===
-The Fab region of the antibody is where antigen recognition occurs upon binding (Figure 1). On each arm is one heavy ('''{{Font color|violet|A}}'''/<b><span class="text-blue">B</span></b>) and one light (<b><span class="text-purple">A</span></b>/<b><span class="text-cyan">B</span></b>) chain, both containing domains identical to their respective counterparts. Repeats of β-sandwiches form the [https://en.wikipedia.org/wiki/Antibody constant and variable domains] within the Fab region as antigen recognition occurs at the variable domain while the constant domain connects it to the rest of the IgM complex. Because the Fab region of IgM is poorly resolved, a structural analysis of an HIV neutralizing antibody called VCR01 was performed to approximate where an antigen would bind to at the  <scene name='95/952714/Variable_region/1'>variable region</scene>. <ref name="Zhou">PMID:20616231</ref>
+The <scene name='95/952713/Fab_region/1'>Fab region</scene> of the antibody is where antigen recognition occurs upon binding (Figure 1). On each arm is one heavy ('''{{Font color|violet|A}}'''/<b><span class="text-blue">B</span></b>) and one light (<b><span class="text-purple">A</span></b>/<b><span class="text-cyan">B</span></b>) chain, both containing domains identical to their respective counterparts. Repeats of β-sandwiches form the [https://en.wikipedia.org/wiki/Antibody constant and variable domains] within the Fab region as antigen recognition occurs at the variable domain while the constant domain connects it to the rest of the IgM complex. Because the Fab region of IgM is poorly resolved, a structural analysis of an HIV neutralizing antibody called VCR01 was performed to approximate where an antigen would bind to at the  <scene name='95/952714/Variable_region/1'>variable region</scene>. <ref name="Zhou">PMID:20616231</ref>
 The IgM-BCR contains areas referred to as [https://en.wikipedia.org/wiki/Complementarity-determining_region complementary-determining regions](CDRs), which are where the antigen makes <scene name='95/952713/Antigen_antibody_contact/4'>contact</scene> with the antibody on the Fab domain. Figure 2 depicts this as a surface representation given that the specific residues within the antigen-binding motif are unknown.