Sandbox Reserved 1791: Difference between revisions
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'''Thyroid Stimulating Hormone Receptor (TSHR)''' is a type of [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. It is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] which is known as thyrotropin. Activation of TSHR is neccessary for activating a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T<sub>3</sub>] and [https://en.wikipedia.org/wiki/Thyroid_hormones T<sub>4</sub>] (Fig 1). | '''Thyroid Stimulating Hormone Receptor (TSHR)''' is a type of [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. It is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] which is known as thyrotropin. Activation of TSHR is neccessary for activating a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T<sub>3</sub>] and [https://en.wikipedia.org/wiki/Thyroid_hormones T<sub>4</sub>] (Fig 1). | ||
== Structure== | == Structure== | ||
TSHR forms a complex with TSH and G<sub>s</sub> proteins. This is called the <scene name=scene name='95/952720/Tsh-tshr-gs_complex/ | TSHR forms a complex with TSH and G<sub>s</sub> proteins. This is called the <scene name=scene name='95/952720/Tsh-tshr-gs_complex/1'>TSH-TSHR-Gs Complex</scene>. | ||
<scene name=scene name='95/952720/Structure_overview_spins/3'>TSHR has 3 main domains</scene>: Leucine Rich Region Domain (coral), the hinge region (blue-purple), and the transmembrane region(rainbow). The leucine-rich region domain is extracellular. This is where TSH will bind. The hinge region is also extracellular. Conformational changes in this region are responsible for the switch between the active vs inactive state. Finally, the transmembrane region is located within the plasma membrane. Its function is to hold the receptor into the membrane. This domain is also bound to the [https://en.wikipedia.org/wiki/G_protein G-proteins] at the N-terminus. The G-proteins are located on the intracellular side of the plasma membrane. They are important for transmitting the binding signal into the cell, setting off a protein signaling cascade. | <scene name=scene name='95/952720/Structure_overview_spins/3'>TSHR has 3 main domains</scene>: Leucine Rich Region Domain (coral), the hinge region (blue-purple), and the transmembrane region(rainbow). The leucine-rich region domain is extracellular. This is where TSH will bind. The hinge region is also extracellular. Conformational changes in this region are responsible for the switch between the active vs inactive state. Finally, the transmembrane region is located within the plasma membrane. Its function is to hold the receptor into the membrane. This domain is also bound to the [https://en.wikipedia.org/wiki/G_protein G-proteins] at the N-terminus. The G-proteins are located on the intracellular side of the plasma membrane. They are important for transmitting the binding signal into the cell, setting off a protein signaling cascade. | ||
=== Transmembrane Region=== | === Transmembrane Region=== | ||
