Sandbox Reserved 1786: Difference between revisions
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='''Human B-cell Antigen Receptor: IgM BCR'''= | ='''Human B-cell Antigen Receptor: IgM BCR'''= | ||
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Furthermore, both the <b><span class="text-brown">Igα</span></b> and <b><span class="text-orange">Igβ</span></b> chains have cytoplasmic tails that extend into the B cell (Figure 1). Each of these tails contain an [https://en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_activation_motif ITAM region] to facilitate signal transduction (Figure 4). <ref name="Ma">PMID:35981028</ref> The structures of the ITAM regions have not yet been determined. | Furthermore, both the <b><span class="text-brown">Igα</span></b> and <b><span class="text-orange">Igβ</span></b> chains have cytoplasmic tails that extend into the B cell (Figure 1). Each of these tails contain an [https://en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_activation_motif ITAM region] to facilitate signal transduction (Figure 4). <ref name="Ma">PMID:35981028</ref> The structures of the ITAM regions have not yet been determined. | ||
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===Fc Region=== | ===Fc Region=== | ||
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To maximize the Fc region’s signal transduction efficiency and Van der Waals contacts, constant region two of '''{{Font color|violet|heavy chain A}}''' makes an asymmetrical association with constant region three of <b><span class="text-blue">heavy chain B</span></b> to create a <scene name='95/952713/Trans_heavy/7'>heavy chain interface</scene>. More specifically, Arg243 and Arg251 residues from '''{{Font color|violet|heavy chain A}}''' donate three hydrogen bonds to Leu433, Thr431, and Asp376 residues on <b><span class="text-blue">heavy chain B</span></b>. Furthermore, Leu313 of heavy chain A accepts a hydrogen bond from Thr429 on heavy chain B. <ref name="Ma">PMID:35981028</ref> | To maximize the Fc region’s signal transduction efficiency and Van der Waals contacts, constant region two of '''{{Font color|violet|heavy chain A}}''' makes an asymmetrical association with constant region three of <b><span class="text-blue">heavy chain B</span></b> to create a <scene name='95/952713/Trans_heavy/7'>heavy chain interface</scene>. More specifically, Arg243 and Arg251 residues from '''{{Font color|violet|heavy chain A}}''' donate three hydrogen bonds to Leu433, Thr431, and Asp376 residues on <b><span class="text-blue">heavy chain B</span></b>. Furthermore, Leu313 of heavy chain A accepts a hydrogen bond from Thr429 on heavy chain B. <ref name="Ma">PMID:35981028</ref> | ||
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===Fab Region=== | ===Fab Region=== | ||
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{{Clear}} | {{Clear}} | ||
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=='''Signal Transduction'''== | =='''Signal Transduction'''== | ||
