Sandbox Reserved 1791: Difference between revisions

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== Active vs. Inactive State ==

In its resting state without TSH, TSHR is in the <scene name='95/952720/Inactivetshr/7'>inactive state</scene>, also ~~considered~~ the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashes between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/6'>active or "up" state</scene>. During this transition, the ~~extracellular LRD rotates~~ 55° along an axis ~~making it~~ perpendicular to the cell membrane. This rotation is initiated by conformational changes within the <scene name='95/~~952720~~/Hinge_region_spin/3'>~~Hinge~~ Region</scene>, specifically at the <scene name='95/952720/Hinge_region_residues/2'>~~TYR279~~ residue</scene>. Y279 moves 6 Å relative to I486, a residue located in the Transmembrane Region <ref name="Faust"/>. The active form is favored when <scene name='95/952719/Active_form/6'>TSHR is bound to TSH</scene>. The structure can be seen as straight. The same straight conformation is observed when TSHR is bound with M22. The inactive form is found when <scene name='95/952719/Inactive_form/7'>TSHR is bound with K1</scene> of TSHR is found when bound with K1. The overall structure of the molecule is bent when K1 is bound.

In its resting state without TSH bound, TSHR is in the <scene name='95/952720/Inactivetshr/8'>inactive state</scene>, also known as the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashes between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/6'>active or "up" state</scene> (fig 2). During this transition, the LRRD rotate 55° along an axis perpendicular to the cell membrane. This rotation is initiated by conformational changes within the <scene name='95/952719/Hinge_region_spin/3'>Higne Region</scene>, specifically at the <scene name='95/952720/Hinge_region_residues/3'>Tyr279 residue</scene>, located in the Hinge Region. Y279 moves 6 Å relative to I486, which is a residue located in the Transmembrane Region nearby Y279<ref name="Faust"/> (Fig 3).

The active form is favored when <scene name='95/952719/Active_form/6'>TSHR is bound to TSH</scene>. The structure can be seen as straight. The same straight conformation is observed when TSHR is bound with M22. The inactive form is found when <scene name='95/952719/Inactive_form/7'>TSHR is bound with K1</scene> of TSHR is found when bound with K1. The overall structure of the molecule is bent when K1 is bound.

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Sandbox Reserved 1791: Difference between revisions

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 == Active vs. Inactive State ==
-In its resting state without TSH, TSHR is in the <scene name='95/952720/Inactivetshr/7'>inactive state</scene>, also considered the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashes between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/6'>active or "up" state</scene>. During this transition, the extracellular LRD rotates 55° along an axis making it perpendicular to the cell membrane. This rotation is initiated by conformational changes within the <scene name='95/952720/Hinge_region_spin/3'>Hinge Region</scene>, specifically at the <scene name='95/952720/Hinge_region_residues/2'>TYR279 residue</scene>. Y279 moves 6 Å relative to I486, a residue located in the Transmembrane Region <ref name="Faust"/>. The active form is favored when <scene name='95/952719/Active_form/6'>TSHR is bound to TSH</scene>. The structure can be seen as straight. The same straight conformation is observed when TSHR is bound with M22. The inactive form is found when <scene name='95/952719/Inactive_form/7'>TSHR is bound with K1</scene> of TSHR is found when bound with K1. The overall structure of the molecule is bent when K1 is bound.
+In its resting state without TSH bound, TSHR is in the <scene name='95/952720/Inactivetshr/8'>inactive state</scene>, also known as the "down" state because the LRRD is pointing down. When TSH binds to TSHR, steric clashes between TSH and the cell-membrane cause TSHR to take on the <scene name='95/952720/Inactivetshr/6'>active or "up" state</scene> (fig 2). During this transition, the LRRD rotate 55° along an axis perpendicular to the cell membrane. This rotation is initiated by conformational changes within the <scene name='95/952719/Hinge_region_spin/3'>Higne Region</scene>, specifically at the <scene name='95/952720/Hinge_region_residues/3'>Tyr279 residue</scene>, located in the Hinge Region. Y279 moves 6 Å relative to I486, which is a residue located in the Transmembrane Region nearby Y279<ref name="Faust"/> (Fig 3).
+The active form is favored when <scene name='95/952719/Active_form/6'>TSHR is bound to TSH</scene>. The structure can be seen as straight. The same straight conformation is observed when TSHR is bound with M22. The inactive form is found when <scene name='95/952719/Inactive_form/7'>TSHR is bound with K1</scene> of TSHR is found when bound with K1. The overall structure of the molecule is bent when K1 is bound.
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