Sandbox Reserved 1791: Difference between revisions

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M22 is an activating antibody for [https://en.wikipedia.org/wiki/Thyrotropin_receptor TSHR]. This antibody mimics [https://my.clevelandclinic.org/health/articles/23524-thyroid-stimulating-hormone-tsh-levels TSH] to activate the thyroid gland to produce [https://www.healthyandnaturalworld.com/t3-t4-thyroid-hormones/ T3 and T4 hormones]. M22 makes a stronger interaction with TSHR than TSH does due to a larger number of hydrogen bonds (14 H bonds for M22 and 3 for TSH) and salt bridge interactions with the concave surface of the LRRD<ref name="M22"> DOI 10.1677/JME-08-0152</ref>. This interaction is key for understanding why M22 activates TSHR and does not release TSHR to go into the inactive state even when T3 and T4 levels are high<ref name="M22"> DOI 10.1677/JME-08-0152</ref>.
M22 is an activating antibody for [https://en.wikipedia.org/wiki/Thyrotropin_receptor TSHR]. This antibody mimics [https://my.clevelandclinic.org/health/articles/23524-thyroid-stimulating-hormone-tsh-levels TSH] to activate the thyroid gland to produce [https://www.healthyandnaturalworld.com/t3-t4-thyroid-hormones/ T3 and T4 hormones]. M22 makes a stronger interaction with TSHR than TSH does due to a larger number of hydrogen bonds (14 H bonds for M22 and 3 for TSH) and salt bridge interactions with the concave surface of the LRRD<ref name="M22"> DOI 10.1677/JME-08-0152</ref>. This interaction is key for understanding why M22 activates TSHR and does not release TSHR to go into the inactive state even when T3 and T4 levels are high<ref name="M22"> DOI 10.1677/JME-08-0152</ref>.
=== K1 ===
=== K1 ===
[https://www.creativebiolabs.net/Anti-TSHR-Recombinant-Antibody-clone-K1-70-24911.htm K1] is an inhibitory antibody. This antibody mimics [https://my.clevelandclinic.org/health/articles/23524-thyroid-stimulating-hormone-tsh-levels TSH] and binds to TSHR with a high affinity which prevents the receptor binding to TSH. K1 puts TSHR in the conformational bent state<ref name="K1"> DOI 10.1111/cen.14681</ref>. It is effective at lowering T3 and T4 levels while increasing TSH concentration.  
[https://www.creativebiolabs.net/Anti-TSHR-Recombinant-Antibody-clone-K1-70-24911.htm K1] is an inhibitory antibody. This antibody mimics [https://my.clevelandclinic.org/health/articles/23524-thyroid-stimulating-hormone-tsh-levels TSH] and binds to TSHR with a high affinity which prevents the receptor binding to TSH. K1 puts TSHR in the conformational bent state. It is effective at lowering T3 and T4 levels while increasing TSH concentration.  
== Active vs. Inactive State ==
== Active vs. Inactive State ==


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