7y7w: Difference between revisions
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The entry | ==Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom== | ||
<StructureSection load='7y7w' size='340' side='right'caption='[[7y7w]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7y7w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y7W FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y7w OCA], [https://pdbe.org/7y7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y7w RCSB], [https://www.ebi.ac.uk/pdbsum/7y7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y7w ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/SC6A1_HUMAN SC6A1_HUMAN] Myoclonic-astatic epilepsy. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SC6A1_HUMAN SC6A1_HUMAN] Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Huang J]] | |||
[[Category: Kong F]] | |||
[[Category: Lei J]] | |||
[[Category: Tan J]] | |||
[[Category: Yan C]] | |||
[[Category: Yuan Y]] | |||
[[Category: Zhu A]] | |||
Revision as of 16:59, 26 April 2023
Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom
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