8adm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8adm is ~~ON HOLD until Paper Publication~~

==Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stabilizer==

~~Authors~~: ~~Centorrino~~, F., ~~Ottmann~~, C.

== Structural highlights ==

<table><tr><td colspan='2'>[[8adm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ADM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ADM FirstGlance]. <br>

~~Description~~: ~~Ternary complex~~ of ~~14-3-3 sigma~~, ~~Usp8pS718 phosphopeptide~~ and ~~small molecule stabilizer~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O6C:1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide'>O6C</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8adm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8adm OCA], [https://pdbe.org/8adm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8adm RCSB], [https://www.ebi.ac.uk/pdbsum/8adm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8adm ProSAT]</span></td></tr>

[[Category: ~~Ottmann, C~~]]

</table>

[[Category: Centorrino, F]]

== Function ==

[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Centorrino F]]

[[Category: Ottmann C]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8adm is ON HOLD  until Paper Publication
+==Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stabilizer==
+<StructureSection load='8adm' size='340' side='right'caption='[[8adm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors: Centorrino, F., Ottmann, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8adm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ADM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ADM FirstGlance]. <br>
-Description: Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stabilizer
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O6C:1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide'>O6C</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8adm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8adm OCA], [https://pdbe.org/8adm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8adm RCSB], [https://www.ebi.ac.uk/pdbsum/8adm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8adm ProSAT]</span></td></tr>
-[[Category: Ottmann, C]]
+</table>
-[[Category: Centorrino, F]]
+== Function ==
+[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Centorrino F]]
+[[Category: Ottmann C]]