4xrs: Difference between revisions

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<StructureSection load='4xrs' size='340' side='right'caption='[[4xrs]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='4xrs' size='340' side='right'caption='[[4xrs]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xrs]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XRS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xrs]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XRS FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MEIS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), DLX3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xrs OCA], [https://pdbe.org/4xrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xrs RCSB], [https://www.ebi.ac.uk/pdbsum/4xrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xrs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xrs OCA], [http://pdbe.org/4xrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xrs RCSB], [http://www.ebi.ac.uk/pdbsum/4xrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xrs ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/DLX3_HUMAN DLX3_HUMAN]] Tricho-dento-osseous syndrome;Hypomaturation-hypoplastic amelogenesis imperfecta with taurodontism. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/MEIS1_HUMAN MEIS1_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/MEIS1_HUMAN MEIS1_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLX3_HUMAN DLX3_HUMAN]] Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. [[http://www.uniprot.org/uniprot/MEIS1_HUMAN MEIS1_HUMAN]] Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.<ref>PMID:12609849</ref>
[https://www.uniprot.org/uniprot/MEIS1_HUMAN MEIS1_HUMAN] Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.<ref>PMID:12609849</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dave, K]]
[[Category: Synthetic construct]]
[[Category: Enge, M]]
[[Category: Dave K]]
[[Category: Jorma, A]]
[[Category: Enge M]]
[[Category: Kivioja, T]]
[[Category: Jorma A]]
[[Category: Morgunova, E]]
[[Category: Kivioja T]]
[[Category: Nitta, K R]]
[[Category: Morgunova E]]
[[Category: Popov, A]]
[[Category: Nitta KR]]
[[Category: Taipale, J]]
[[Category: Popov A]]
[[Category: Yin, Y]]
[[Category: Taipale J]]
[[Category: Dna]]
[[Category: Yin Y]]
[[Category: Heterodimer]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/4xrs"