4y07: Difference between revisions

<table><tr><td colspan='2'>[[4y07]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y07 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y07 OCA], [https://pdbe.org/4y07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y07 RCSB], [https://www.ebi.ac.uk/pdbsum/4y07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y07 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/WWP2_HUMAN WWP2_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.<ref>PMID:19274063</ref> <ref>PMID:19651900</ref>  

*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Gong W]]

[[Category: Li J]]

[[Category: Li Z]]

[[Category: Xu Y]]