7utt: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7utt is ~~ON HOLD until Paper Publication~~

==Structure of Non-hydrolyzable ATP (ApCpp) binds to Cyclic GMP AMP synthase (cGAS) through Mn coordination==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7utt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UTT FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7utt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7utt OCA], [https://pdbe.org/7utt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7utt RCSB], [https://www.ebi.ac.uk/pdbsum/7utt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7utt ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

__TOC__

</StructureSection>

[[Category: DNA molecule]]

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Gabelli SB]]

[[Category: Sohn J]]

[[Category: Wu S]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7utt is ON HOLD  until Paper Publication
+==Structure of Non-hydrolyzable ATP (ApCpp) binds to Cyclic GMP AMP synthase (cGAS) through Mn coordination==
+<StructureSection load='7utt' size='340' side='right'caption='[[7utt]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7utt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UTT FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7utt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7utt OCA], [https://pdbe.org/7utt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7utt RCSB], [https://www.ebi.ac.uk/pdbsum/7utt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7utt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
+__TOC__
+</StructureSection>
+[[Category: DNA molecule]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Gabelli SB]]
+[[Category: Sohn J]]
+[[Category: Wu S]]