4yb4: Difference between revisions

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<StructureSection load='4yb4' size='340' side='right'caption='[[4yb4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4yb4' size='340' side='right'caption='[[4yb4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yb4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YB4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yb4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YB4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48Y:(1R,2S)-1-HYDROXYBUTANE-1,2,4-TRICARBOXYLIC+ACID'>48Y</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48Y:(1R,2S)-1-HYDROXYBUTANE-1,2,4-TRICARBOXYLIC+ACID'>48Y</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hicd, hdh, hicdh, TT_C1012 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=262724 THET2])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yb4 OCA], [https://pdbe.org/4yb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yb4 RCSB], [https://www.ebi.ac.uk/pdbsum/4yb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yb4 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoisocitrate_dehydrogenase Homoisocitrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.87 1.1.1.87] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yb4 OCA], [http://pdbe.org/4yb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yb4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yb4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HICDH_THET2 HICDH_THET2]] Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate. In addition, has high activity with citrate, but is inactive with 3-isopropylmalate.<ref>PMID:12427751</ref> <ref>PMID:20735360</ref>
[https://www.uniprot.org/uniprot/HICDH_THET2 HICDH_THET2] Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate. In addition, has high activity with citrate, but is inactive with 3-isopropylmalate.<ref>PMID:12427751</ref> <ref>PMID:20735360</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homoisocitrate dehydrogenase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Thet2]]
[[Category: Thermus thermophilus HB27]]
[[Category: Kuzuyama, T]]
[[Category: Kuzuyama T]]
[[Category: Nishiyama, M]]
[[Category: Nishiyama M]]
[[Category: Takahashi, K]]
[[Category: Takahashi K]]
[[Category: Tomita, T]]
[[Category: Tomita T]]
[[Category: Homoisocitrate dehydrogenase thermus thermophilus]]
[[Category: Oxidoreductase]]

Revision as of 08:06, 3 May 2023

Crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium ion (II) and NADH

4yb4, resolution 2.50Å

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