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==Structural characterization of a synaptic adhesion complex==
==Structural characterization of a synaptic adhesion complex==
<StructureSection load='4yeb' size='340' side='right' caption='[[4yeb]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
<StructureSection load='4yeb' size='340' side='right'caption='[[4yeb]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yeb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YEB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yeb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YEB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rmk|4rmk]], [[4rml|4rml]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yeb OCA], [https://pdbe.org/4yeb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yeb RCSB], [https://www.ebi.ac.uk/pdbsum/4yeb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yeb ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Lphn3, Kiaa0768, Lec3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Flrt3, mCG_130708 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yeb OCA], [http://pdbe.org/4yeb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yeb RCSB], [http://www.ebi.ac.uk/pdbsum/4yeb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yeb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LPHN3_MOUSE LPHN3_MOUSE]] May be involved in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.<ref>PMID:24739570</ref>
[https://www.uniprot.org/uniprot/AGRL3_MOUSE AGRL3_MOUSE] Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25728924, PubMed:26235031). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570).<ref>PMID:22405201</ref> <ref>PMID:24739570</ref> <ref>PMID:25728924</ref> <ref>PMID:26235031</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yeb" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yeb" style="background-color:#fffaf0;"></div>
==See Also==
*[[Latrophilin|Latrophilin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Bergami, F]]
[[Category: Mus musculus]]
[[Category: Comoletti, D]]
[[Category: Bergami F]]
[[Category: Daake, S von]]
[[Category: Comoletti D]]
[[Category: Demeler, B]]
[[Category: Demeler B]]
[[Category: Hendrickson, W A]]
[[Category: Hendrickson WA]]
[[Category: Lee, D]]
[[Category: Lee D]]
[[Category: Li, S]]
[[Category: Li S]]
[[Category: Liu, Q]]
[[Category: Liu Q]]
[[Category: Martini, F]]
[[Category: Martini F]]
[[Category: Ranaivoson, F M]]
[[Category: Ranaivoson FM]]
[[Category: Central nervous system]]
[[Category: Von Daake S]]
[[Category: Complex]]
[[Category: Flrt3]]
[[Category: Latrophilin 3]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4yeb"