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==Crystal structure of human BRD4(1) in complex with 4-[(2E)-3-(4-methoxyphenyl)-2-phenylprop-2-enoyl]-3,4-dihydroquinoxalin-2(1H)-one (compound 19a)==
==Crystal structure of human BRD4(1) in complex with 4-[(2E)-3-(4-methoxyphenyl)-2-phenylprop-2-enoyl]-3,4-dihydroquinoxalin-2(1H)-one (compound 19a)==
<StructureSection load='4yh3' size='340' side='right' caption='[[4yh3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4yh3' size='340' side='right'caption='[[4yh3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yh3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YH3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yh3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YH3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y80:4-[(2E)-3-(4-METHOXYPHENYL)-2-PHENYLPROP-2-ENOYL]-3,4-DIHYDROQUINOXALIN-2(1H)-ONE'>Y80</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y80:4-[(2E)-3-(4-METHOXYPHENYL)-2-PHENYLPROP-2-ENOYL]-3,4-DIHYDROQUINOXALIN-2(1H)-ONE'>Y80</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yh4|4yh4]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yh3 OCA], [https://pdbe.org/4yh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yh3 RCSB], [https://www.ebi.ac.uk/pdbsum/4yh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yh3 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yh3 OCA], [http://pdbe.org/4yh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yh3 RCSB], [http://www.ebi.ac.uk/pdbsum/4yh3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yh3 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).  
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yh3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yh3" style="background-color:#fffaf0;"></div>
==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Lakshminarasimhan, D]]
[[Category: Large Structures]]
[[Category: Suto, R K]]
[[Category: Lakshminarasimhan D]]
[[Category: White, A]]
[[Category: Suto RK]]
[[Category: Protein binding]]
[[Category: White A]]
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