4yhj: Difference between revisions

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<StructureSection load='4yhj' size='340' side='right'caption='[[4yhj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4yhj' size='340' side='right'caption='[[4yhj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yhj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YHJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yhj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YHJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AN2:AMP+PHOSPHORAMIDATE'>AN2</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AN2:AMP+PHOSPHORAMIDATE'>AN2</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRK4, GPRK2L, GPRK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yhj OCA], [https://pdbe.org/4yhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yhj RCSB], [https://www.ebi.ac.uk/pdbsum/4yhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yhj ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[G-protein-coupled_receptor]_kinase [G-protein-coupled receptor] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.16 2.7.11.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yhj OCA], [http://pdbe.org/4yhj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yhj RCSB], [http://www.ebi.ac.uk/pdbsum/4yhj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yhj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GRK4_HUMAN GRK4_HUMAN]] Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.<ref>PMID:19520868</ref> <ref>PMID:8626439</ref>
[https://www.uniprot.org/uniprot/GRK4_HUMAN GRK4_HUMAN] Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.<ref>PMID:19520868</ref> <ref>PMID:8626439</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Allen, S J]]
[[Category: Allen SJ]]
[[Category: Munshi, S]]
[[Category: Munshi S]]
[[Category: Parthasarathy, G]]
[[Category: Parthasarathy G]]
[[Category: Soisson, S]]
[[Category: Soisson S]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4yhj"