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==Crystal structure of Elk prion protein complexed with POM1 FAB==
==Crystal structure of Elk prion protein complexed with POM1 FAB==
<StructureSection load='4yxk' size='340' side='right' caption='[[4yxk]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
<StructureSection load='4yxk' size='340' side='right'caption='[[4yxk]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yxk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/American_elk American elk] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXK FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yxk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cervus_canadensis_nelsoni Cervus canadensis nelsoni] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yx2|4yx2]], [[4yxh|4yxh]], [[4yxl|4yxl]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxk OCA], [https://pdbe.org/4yxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxk RCSB], [https://www.ebi.ac.uk/pdbsum/4yxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxk ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRNP, PRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9864 American elk])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxk OCA], [http://pdbe.org/4yxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxk RCSB], [http://www.ebi.ac.uk/pdbsum/4yxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxk ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN]] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.  
[https://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).  
[https://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yxk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yxk" style="background-color:#fffaf0;"></div>
==See Also==
*[[Prion 3D structures|Prion 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: American elk]]
[[Category: Cervus canadensis nelsoni]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Baral, P K]]
[[Category: Mus musculus]]
[[Category: James, M N.G]]
[[Category: Baral PK]]
[[Category: Swayampakula, M]]
[[Category: James MNG]]
[[Category: Antibody]]
[[Category: Swayampakula M]]
[[Category: Immune system]]
[[Category: Immune system complex]]
[[Category: Prion]]
Retrieved from "https://proteopedia.org/4yxk"