8i0n: Difference between revisions

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'''Unreleased structure'''


The entry 8i0n is ON HOLD  until Paper Publication
==Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 (Local refine)==
 
<StructureSection load='8i0n' size='340' side='right'caption='[[8i0n]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
Authors: Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8i0n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I0N FirstGlance]. <br>
Description: Structure of arrestin bound to peptide 1 -Local refine
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i0n OCA], [https://pdbe.org/8i0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i0n RCSB], [https://www.ebi.ac.uk/pdbsum/8i0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i0n ProSAT]</span></td></tr>
[[Category: Shukla, A.K]]
</table>
[[Category: Yadav, M.K]]
== Function ==
[[Category: Sarma, P]]
[https://www.uniprot.org/uniprot/C5AR1_HUMAN C5AR1_HUMAN] Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).<ref>PMID:10636859</ref> <ref>PMID:15153520</ref> <ref>PMID:1847994</ref> <ref>PMID:7622471</ref> <ref>PMID:8182049</ref> <ref>PMID:9553099</ref>
[[Category: Maharana, J]]
== References ==
[[Category: Banerjee, R]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Rattus norvegicus]]
[[Category: Banerjee R]]
[[Category: Maharana J]]
[[Category: Sarma P]]
[[Category: Shukla AK]]
[[Category: Yadav MK]]
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