4zfz: Difference between revisions

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<StructureSection load='4zfz' size='340' side='right'caption='[[4zfz]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
<StructureSection load='4zfz' size='340' side='right'caption='[[4zfz]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zfz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zfz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_(F236/SMH4_ISOLATE)_(SOOTY_MANGABEY) Simian immunodeficiency virus (F236/SMH4 ISOLATE) (SOOTY MANGABEY)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfz OCA], [https://pdbe.org/4zfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfz RCSB], [https://www.ebi.ac.uk/pdbsum/4zfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfz OCA], [http://pdbe.org/4zfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfz RCSB], [http://www.ebi.ac.uk/pdbsum/4zfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NEF_SIVS4 NEF_SIVS4]] Seems to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity. Probably involved in viral immune evasion mechanisms (By similarity).  In infected CD4(+) T-lymphocytes, down-regulates cell surface expression of CD4, CD28, CD3, and MHC-I or MHC-II molecules.<ref>PMID:16051847</ref>  Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes.<ref>PMID:16051847</ref>  [[http://www.uniprot.org/uniprot/B2MG_MACMU B2MG_MACMU]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
[https://www.uniprot.org/uniprot/K4MU32_MACMU K4MU32_MACMU]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[MHC 3D structures of MHC|MHC 3D structures of MHC]]
*[[MHC 3D structures|MHC 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Macmu]]
[[Category: Macaca mulatta]]
[[Category: Morita, D]]
[[Category: Morita D]]
[[Category: Sugita, M]]
[[Category: Sugita M]]
[[Category: Aid]]
[[Category: Antigen presentation]]
[[Category: Immune system]]
[[Category: Lipopeptide]]
[[Category: Mhc]]
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