4zig: Difference between revisions

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<StructureSection load='4zig' size='340' side='right'caption='[[4zig]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4zig' size='340' side='right'caption='[[4zig]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zig]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZIG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zig]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZIG FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zie|4zie]], [[4zih|4zih]], [[4zii|4zii]], [[4zif|4zif]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zig OCA], [https://pdbe.org/4zig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zig RCSB], [https://www.ebi.ac.uk/pdbsum/4zig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zig ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAX, BCL2L4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zig OCA], [http://pdbe.org/4zig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zig RCSB], [http://www.ebi.ac.uk/pdbsum/4zig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zig ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref> [[http://www.uniprot.org/uniprot/BID_HUMAN BID_HUMAN]] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.<ref>PMID:14583606</ref> 
[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Colman, P M]]
[[Category: Colman PM]]
[[Category: Czabotar, P E]]
[[Category: Czabotar PE]]
[[Category: Dewson, G]]
[[Category: Dewson G]]
[[Category: Kumar, K Krishna]]
[[Category: Krishna Kumar K]]
[[Category: Robin, A Y]]
[[Category: Robin AY]]
[[Category: Thompson, G V]]
[[Category: Thompson GV]]
[[Category: Wardak, A Z]]
[[Category: Wardak AZ]]
[[Category: Westphal, D]]
[[Category: Westphal D]]
[[Category: Apoptosis]]
[[Category: Bax]]
[[Category: Bh3 domain]]
[[Category: Structural genomic]]
[[Category: The walter and eliza hall institute of medical research]]
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