4zj8: Difference between revisions
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<StructureSection load='4zj8' size='340' side='right'caption='[[4zj8]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='4zj8' size='340' side='right'caption='[[4zj8]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4zj8]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4zj8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJ8 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zj8 OCA], [https://pdbe.org/4zj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zj8 RCSB], [https://www.ebi.ac.uk/pdbsum/4zj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zj8 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Brautigam | [[Category: Pyrococcus abyssi GE5]] | ||
[[Category: Clark | [[Category: Brautigam CA]] | ||
[[Category: Coleman | [[Category: Clark L]] | ||
[[Category: Gotter | [[Category: Coleman P]] | ||
[[Category: Harrell | [[Category: Gotter AL]] | ||
[[Category: Renger | [[Category: Harrell CM]] | ||
[[Category: Rosenbaum | [[Category: Renger JJ]] | ||
[[Category: Shao | [[Category: Rosenbaum DM]] | ||
[[Category: Yin | [[Category: Shao Z]] | ||
[[Category: Yin J]] | |||