4zjr: Difference between revisions

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==RORgamma in complex with inverse agonist 48==
==RORgamma in complex with inverse agonist 48==
<StructureSection load='4zjr' size='340' side='right' caption='[[4zjr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4zjr' size='340' side='right'caption='[[4zjr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zjr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zjr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4P3:6-CHLORO-4-[(2-CHLORO-6-FLUOROBENZOYL)(METHYL)AMINO]-3-(2,2,2-TRIFLUOROETHOXY)BIPHENYL-3-CARBOXAMIDE'>4P3</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4P3:6-CHLORO-4-[(2-CHLORO-6-FLUOROBENZOYL)(METHYL)AMINO]-3-(2,2,2-TRIFLUOROETHOXY)BIPHENYL-3-CARBOXAMIDE'>4P3</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RORC, NR1F3, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjr OCA], [https://pdbe.org/4zjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zjr RCSB], [https://www.ebi.ac.uk/pdbsum/4zjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjr OCA], [http://pdbe.org/4zjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjr RCSB], [http://www.ebi.ac.uk/pdbsum/4zjr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.  
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Marcotte, D J]]
[[Category: Large Structures]]
[[Category: Inverse agonist]]
[[Category: Marcotte DJ]]
[[Category: Rorgamma ligand binding domain]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/4zjr"