4zyh: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[4zyh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYH OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZYH FirstGlance].

<table><tr><td colspan='2'>[[4zyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYH OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4ZYH FirstGlance].

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">ogt, SSO2487 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4zyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyh OCA], [https://pdbe.org/4zyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zyh RCSB], [https://www.ebi.ac.uk/pdbsum/4zyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyh ProSAT]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyh OCA], [~~http~~://pdbe.org/4zyh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zyh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zyh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyh ProSAT]</td></tr>

</table>

== Function ==

[~~[http~~://www.uniprot.org/uniprot/~~OGT_SULSO OGT_SULSO]~~] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs ~~alkylated guanine~~ in DNA by stoichiometrically transferring the ~~alkyl~~ group ~~at the O-6 position~~ to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

[https://www.uniprot.org/uniprot/OGT_SACS2 OGT_SACS2] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.[HAMAP-Rule:MF_00772]

== Publication Abstract from PubMed ==

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__TOC__

</StructureSection>

~~[[Category: Atcc 35091]]~~

[[Category: Large Structures]]

[[Category: ~~Miggiano, R~~]]

[[Category: Saccharolobus solfataricus]]

[[Category: ~~Rizzi, M~~]]

[[Category: Miggiano R]]

[[Category: ~~Rossi, F~~]]

[[Category: Rizzi M]]

[[Category: ~~Alkylated dna-protein alkyltransferase]]~~

[[Category: Rossi F]]

~~[[Category: Dna repair]]~~

~~[[Category: Extremophile]]~~

~~[[Category: Transferase~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='4zyh' size='340' side='right'caption='[[4zyh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4zyh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZYH FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4zyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZYH FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ogt, SSO2487 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyh OCA], [https://pdbe.org/4zyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zyh RCSB], [https://www.ebi.ac.uk/pdbsum/4zyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyh ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyh OCA], [http://pdbe.org/4zyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zyh RCSB], [http://www.ebi.ac.uk/pdbsum/4zyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyh ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/OGT_SULSO OGT_SULSO]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
+[https://www.uniprot.org/uniprot/OGT_SACS2 OGT_SACS2] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.[HAMAP-Rule:MF_00772]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 26: / Line 24: @@
 __TOC__
 </StructureSection>
-[[Category: Atcc 35091]]
 [[Category: Large Structures]]
-[[Category: Miggiano, R]]
+[[Category: Saccharolobus solfataricus]]
-[[Category: Rizzi, M]]
+[[Category: Miggiano R]]
-[[Category: Rossi, F]]
+[[Category: Rizzi M]]
-[[Category: Alkylated dna-protein alkyltransferase]]
+[[Category: Rossi F]]
-[[Category: Dna repair]]
-[[Category: Extremophile]]
-[[Category: Transferase]]