5a23: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[5a23]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A23 OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A23 FirstGlance].

<table><tr><td colspan='2'>[[5a23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A23 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5A23 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a23 OCA], [~~http~~://pdbe.org/5a23 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a23 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a23 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a23 ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5a23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a23 OCA], [https://pdbe.org/5a23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a23 RCSB], [https://www.ebi.ac.uk/pdbsum/5a23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a23 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/LPAKS_PSEAE LPAKS_PSEAE] Alkylsulfatase that cleaves both short and medium-length alkylsulfates, including the widely used detergent sodium dodecyl sulfate (SDS) (PubMed:16684886). Acts in vitro on primary alkylsulfates such as decyl sulfate, octyl sulfate and hexyl sulfate, but not on sulfated sugars and arylsulfates (PubMed:16684886, PubMed:23061549). The hydrolysis of SDS allows the bacterium to use SDS as a sole carbon or sulfur source (PubMed:16684886). In addition, contributes to the in vivo virulence of P.aeruginosa by playing a central role in the degradation of mucin, a glycoprotein that is the primary component of the mucus overlaying the host epithelial tissues (PubMed:31907968). Plays a role in the degradation of both protein and carbohydrate moieties in mucin via the release of sulfate from mucin, D-galactose 6-sulfate (Gal-6S) and N-acetyl-D-glucosamine 6-sulfate (GlcNAc-6S) (PubMed:31907968).<ref>PMID:16684886</ref> <ref>PMID:23061549</ref> <ref>PMID:31907968</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: ~~Flores-Hernandez, E]]~~

[[Category: Pseudomonas aeruginosa]]

~~[[Category: Jakoncik, J~~]]

[[Category: De la Mora E]]

[[Category: Mora, E ~~De la~~]]

[[Category: Flores-Hernandez E]]

[[Category: ~~Moreno, A]]~~

[[Category: Jakoncik J]]

~~[[Category: Sanchez~~-~~Puig, N~~]]

[[Category: Moreno A]]

[[Category: ~~Stojanoff, V~~]]

[[Category: Sanchez-Puig N]]

[[Category: ~~Hydrolase~~]]

[[Category: Stojanoff V]]

[[Category: ~~Polymorph~~]]

[[Category: ~~Sdsa sulfatase~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='5a23' size='340' side='right'caption='[[5a23]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5a23]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A23 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5a23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A23 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a23 OCA], [http://pdbe.org/5a23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a23 RCSB], [http://www.ebi.ac.uk/pdbsum/5a23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a23 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a23 OCA], [https://pdbe.org/5a23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a23 RCSB], [https://www.ebi.ac.uk/pdbsum/5a23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a23 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LPAKS_PSEAE LPAKS_PSEAE] Alkylsulfatase that cleaves both short and medium-length alkylsulfates, including the widely used detergent sodium dodecyl sulfate (SDS) (PubMed:16684886). Acts in vitro on primary alkylsulfates such as decyl sulfate, octyl sulfate and hexyl sulfate, but not on sulfated sugars and arylsulfates (PubMed:16684886, PubMed:23061549). The hydrolysis of SDS allows the bacterium to use SDS as a sole carbon or sulfur source (PubMed:16684886). In addition, contributes to the in vivo virulence of P.aeruginosa by playing a central role in the degradation of mucin, a glycoprotein that is the primary component of the mucus overlaying the host epithelial tissues (PubMed:31907968). Plays a role in the degradation of both protein and carbohydrate moieties in mucin via the release of sulfate from mucin, D-galactose 6-sulfate (Gal-6S) and N-acetyl-D-glucosamine 6-sulfate (GlcNAc-6S) (PubMed:31907968).<ref>PMID:16684886</ref> <ref>PMID:23061549</ref> <ref>PMID:31907968</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Flores-Hernandez, E]]
+[[Category: Pseudomonas aeruginosa]]
-[[Category: Jakoncik, J]]
+[[Category: De la Mora E]]
-[[Category: Mora, E De la]]
+[[Category: Flores-Hernandez E]]
-[[Category: Moreno, A]]
+[[Category: Jakoncik J]]
-[[Category: Sanchez-Puig, N]]
+[[Category: Moreno A]]
-[[Category: Stojanoff, V]]
+[[Category: Sanchez-Puig N]]
-[[Category: Hydrolase]]
+[[Category: Stojanoff V]]
-[[Category: Polymorph]]
-[[Category: Sdsa sulfatase]]