7y1f: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7y1f is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of human k-opioid receptor-Gi complex==

~~Authors~~: ~~Chen~~, B.O., ~~Xu, F~~.E.

== Structural highlights ==

<table><tr><td colspan='2'>[[7y1f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y1F FirstGlance]. <br>

~~Description~~: ~~KOR COMPLEX~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y1f OCA], [https://pdbe.org/7y1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y1f RCSB], [https://www.ebi.ac.uk/pdbsum/7y1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y1f ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

[[Category: ~~Xu, F.E~~]]

== Function ==

[[Category: ~~Chen, B.O~~]]

[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chen BO]]

[[Category: Xu FE]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7y1f is ON HOLD  until Paper Publication
+==Cryo-EM structure of human k-opioid receptor-Gi complex==
+<StructureSection load='7y1f' size='340' side='right'caption='[[7y1f]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-Authors: Chen, B.O., Xu, F.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7y1f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y1F FirstGlance]. <br>
-Description: KOR COMPLEX
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y1f OCA], [https://pdbe.org/7y1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y1f RCSB], [https://www.ebi.ac.uk/pdbsum/7y1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y1f ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Xu, F.E]]
+== Function ==
-[[Category: Chen, B.O]]
+[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen BO]]
+[[Category: Xu FE]]