7y8i: Difference between revisions
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==Crystal structure of sDscam FNIII3 domain, isoform alpha7== | |||
<StructureSection load='7y8i' size='340' side='right'caption='[[7y8i]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7y8i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chelicerata Chelicerata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y8I FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y8i OCA], [https://pdbe.org/7y8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y8i RCSB], [https://www.ebi.ac.uk/pdbsum/7y8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y8i ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A159W468_MESMA A0A159W468_MESMA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
To create a functional neural circuit, neurons develop a molecular identity to discriminate self from non-self. The invertebrate Dscam family and vertebrate Pcdh family are implicated in determining synaptic specificity. Recently identified in Chelicerata, a shortened Dscam (sDscam) has been shown to resemble the isoform-generating characters of both Dscam and Pcdh and represent an evolutionary transition. Here we presented the molecular details of sDscam self-recognition via both trans and cis interactions using X-ray crystallographic data and functional assays. Based on our results, we proposed a molecular zipper model for the assemblies of sDscam to mediate cell-cell recognition. In this model, sDscam utilized FNIII domain to form side-by-side interactions with neighboring molecules in the same cell while established hand-in-hand interactions via Ig1 domain with molecules from another cell around. Together, our study provided a framework for understanding the assembly, recognition, and evolution of sDscam. | |||
Structural basis for the self-recognition of sDSCAM in Chelicerata.,Cheng J, Yu Y, Wang X, Zheng X, Liu T, Hu D, Jin Y, Lai Y, Fu TM, Chen Q Nat Commun. 2023 May 2;14(1):2522. doi: 10.1038/s41467-023-38205-1. PMID:37130844<ref>PMID:37130844</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 7y8i" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chelicerata]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen Q]] | |||
[[Category: Cheng J]] | |||
[[Category: Yu Y]] | |||
Revision as of 03:59, 25 May 2023
Crystal structure of sDscam FNIII3 domain, isoform alpha7
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