5a3t: Difference between revisions

<table><tr><td colspan='2'>[[5a3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A3T FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MMK:2-{[(2-{[(E)-2-(DIMETHYLAMINO)ETHENYL](ETHYL)AMINO}-2-OXOETHYL)AMINO]METHYL}PYRIDINE-4-CARBOXYLIC+ACID'>MMK</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3t OCA], [https://pdbe.org/5a3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a3t RCSB], [https://www.ebi.ac.uk/pdbsum/5a3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3t ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>  

*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]

*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: BurgessBrown NA]]

[[Category: Edwards AM]]

[[Category: Gileadi C]]

[[Category: Johansson C]]

[[Category: Kopec J]]

[[Category: Kupinska K]]

[[Category: Oppermann U]]

[[Category: Srikannathasan V]]

[[Category: Strain-Damerell C]]

[[Category: Von Delft F]]