5a5z: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,090 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,090 edits
No edit summary
Line 1: Line 1:


==Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria==
==Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria==
<StructureSection load='5a5z' size='340' side='right' caption='[[5a5z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5a5z' size='340' side='right'caption='[[5a5z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A5Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A5Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WJZ:TIOPRONIN'>WJZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WJZ:TIOPRONIN'>WJZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5z OCA], [https://pdbe.org/5a5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a5z RCSB], [https://www.ebi.ac.uk/pdbsum/5a5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5z OCA], [http://pdbe.org/5a5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a5z RCSB], [http://www.ebi.ac.uk/pdbsum/5a5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.  
[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 20:


==See Also==
==See Also==
*[[Beta-lactamase|Beta-lactamase]]
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Klebsiella pneumoniae]]
[[Category: Cuesta-Bernal, J]]
[[Category: Large Structures]]
[[Category: El-Delik, J]]
[[Category: Cuesta-Bernal J]]
[[Category: Frank, D]]
[[Category: El-Delik J]]
[[Category: Goettig, S]]
[[Category: Frank D]]
[[Category: Klingler, F M]]
[[Category: Goettig S]]
[[Category: Koenigs, A]]
[[Category: Klingler FM]]
[[Category: Mueller, H F]]
[[Category: Koenigs A]]
[[Category: Pogoryelov, D]]
[[Category: Mueller HF]]
[[Category: Proschak, E]]
[[Category: Pogoryelov D]]
[[Category: Sjuts, H]]
[[Category: Proschak E]]
[[Category: Wichelhaus, T A]]
[[Category: Sjuts H]]
[[Category: Hydrolase]]
[[Category: Wichelhaus TA]]
[[Category: Metallo-beta-lactamase]]
[[Category: Ndm-1]]
[[Category: New delhi metallo- beta-lactamase 1]]
[[Category: Tiopronin]]

Revision as of 04:40, 25 May 2023

Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria

5a5z, resolution 2.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=5a5z&oldid=3771878"