5a6r: Difference between revisions
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<StructureSection load='5a6r' size='340' side='right'caption='[[5a6r]], [[Resolution|resolution]] 2.85Å' scene=''> | <StructureSection load='5a6r' size='340' side='right'caption='[[5a6r]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5a6r]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5a6r]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A6R FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a6r OCA], [https://pdbe.org/5a6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a6r RCSB], [https://www.ebi.ac.uk/pdbsum/5a6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a6r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/KCD17_HUMAN KCD17_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KCD17_HUMAN KCD17_HUMAN] Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243).<ref>PMID:25270598</ref> <ref>PMID:25983243</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Bullock | [[Category: Bullock A]] | ||
[[Category: Burgess-Brown | [[Category: Burgess-Brown NA]] | ||
[[Category: Carpenter | [[Category: Carpenter EP]] | ||
[[Category: Chalk | [[Category: Chalk R]] | ||
[[Category: Edwards AM]] | |||
[[Category: Edwards | [[Category: Faust B]] | ||
[[Category: Faust | [[Category: Goubin S]] | ||
[[Category: Goubin | [[Category: Kopec J]] | ||
[[Category: Kopec | [[Category: Krojer T]] | ||
[[Category: Krojer | [[Category: MacKenzie A]] | ||
[[Category: MacKenzie | [[Category: Neshich I]] | ||
[[Category: Neshich | [[Category: Newman JA]] | ||
[[Category: Newman | [[Category: Pearce NM]] | ||
[[Category: Pearce | [[Category: Pike ACW]] | ||
[[Category: Pike | [[Category: Pinkas DM]] | ||
[[Category: Pinkas | [[Category: Quigley A]] | ||
[[Category: Quigley | [[Category: Sanvitale CE]] | ||
[[Category: Sanvitale | [[Category: Sorrell F]] | ||
[[Category: Sorrell | [[Category: Tallant C]] | ||
[[Category: Tallant | [[Category: Williams E]] | ||
[[Category: Williams | [[Category: Von Delft F]] | ||
[[Category: | |||
