5a7j: Difference between revisions

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<StructureSection load='5a7j' size='340' side='right'caption='[[5a7j]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5a7j' size='340' side='right'caption='[[5a7j]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a7j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A7J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5A7J FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a7j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A7J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K2Y:BENZENE+1,2,4,5-TETRAYL+TETRAKIS[DIHYDROGEN+(PHOSPHATE)]'>K2Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K2Y:BENZENE+1,2,4,5-TETRAYL+TETRAKIS[DIHYDROGEN+(PHOSPHATE)]'>K2Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a7i|5a7i]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a7j OCA], [https://pdbe.org/5a7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a7j RCSB], [https://www.ebi.ac.uk/pdbsum/5a7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a7j ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5a7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a7j OCA], [http://pdbe.org/5a7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a7j RCSB], [http://www.ebi.ac.uk/pdbsum/5a7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a7j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN]] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>
[https://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphoinositide 5-phosphatase]]
[[Category: Cozier G]]
[[Category: Cozier, G]]
[[Category: Mills SJ]]
[[Category: Mills, S J]]
[[Category: Nordlund P]]
[[Category: Nordlund, P]]
[[Category: Potter BVL]]
[[Category: Potter, B V.L]]
[[Category: Silvander C]]
[[Category: Silvander, C]]
[[Category: Tresaugues L]]
[[Category: Tresaugues, L]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Magnesium binding]]
[[Category: Phosphoinositides signalling]]
[[Category: Protein-inhbitor complex]]
[[Category: Sgc]]
[[Category: Signalling]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/5a7j"