5ab8: Difference between revisions

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==High resolution X-ray structure of the N-terminal truncated form (residues 1-11) of Mycobacterium tuberculosis HbN==
==High resolution X-ray structure of the N-terminal truncated form (residues 1-11) of Mycobacterium tuberculosis HbN==
<StructureSection load='5ab8' size='340' side='right' caption='[[5ab8]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
<StructureSection load='5ab8' size='340' side='right'caption='[[5ab8]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ab8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AB8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ab8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AB8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ab8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ab8 OCA], [http://pdbe.org/5ab8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ab8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ab8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ab8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ab8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ab8 OCA], [https://pdbe.org/5ab8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ab8 RCSB], [https://www.ebi.ac.uk/pdbsum/5ab8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ab8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TRHBN_MYCTU TRHBN_MYCTU]] Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(-1)) rate.  
[https://www.uniprot.org/uniprot/TRHBN_MYCTU TRHBN_MYCTU] Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(-1)) rate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ascenzi, P]]
[[Category: Large Structures]]
[[Category: Bidon-Chanal, A]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Boechi, L]]
[[Category: Ascenzi P]]
[[Category: Bolognesi, M]]
[[Category: Bidon-Chanal A]]
[[Category: Bustamante, J P]]
[[Category: Boechi L]]
[[Category: Estrin, D A]]
[[Category: Bolognesi M]]
[[Category: Guertin, M]]
[[Category: Bustamante JP]]
[[Category: Luque, F J]]
[[Category: Estrin DA]]
[[Category: Nardini, M]]
[[Category: Guertin M]]
[[Category: Pesce, A]]
[[Category: Luque FJ]]
[[Category: Sebilo, A]]
[[Category: Nardini M]]
[[Category: 2/2 hemoglobin]]
[[Category: Pesce A]]
[[Category: Bacterial globin]]
[[Category: Sebilo A]]
[[Category: Globin dynamic]]
[[Category: Heme/ligand tunneling]]
[[Category: No dioxygenase]]
[[Category: Oxygen transport]]
[[Category: Truncated hemoglobin]]
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