8c9k: Difference between revisions
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==Structure of Mpox virus poxin== | |||
<StructureSection load='8c9k' size='340' side='right'caption='[[8c9k]], [[Resolution|resolution]] 1.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8c9k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C9K FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c9k OCA], [https://pdbe.org/8c9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c9k RCSB], [https://www.ebi.ac.uk/pdbsum/8c9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c9k ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: Boura | [https://www.uniprot.org/uniprot/POXIN_MONPV POXIN_MONPV] Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Monkeypox virus]] | |||
[[Category: Boura E]] | |||
[[Category: Duchoslav V]] | |||
