5amf: Difference between revisions
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==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment Ethyl 4,5,6,7- tetrahydro-1H-indazole-5-carboxylate (SGC - Diamond I04-1 fragment screening)== | ==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment Ethyl 4,5,6,7- tetrahydro-1H-indazole-5-carboxylate (SGC - Diamond I04-1 fragment screening)== | ||
<StructureSection load='5amf' size='340' side='right' | <StructureSection load='5amf' size='340' side='right'caption='[[5amf]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5amf]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5amf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMF FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TWL:ETHYL+(5R)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE-5-CARBOXYLATE'>TWL</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TWL:ETHYL+(5R)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE-5-CARBOXYLATE'>TWL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amf OCA], [https://pdbe.org/5amf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amf RCSB], [https://www.ebi.ac.uk/pdbsum/5amf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amf ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> | ||
==See Also== | ==See Also== | ||
*[[Bromodomain-containing protein|Bromodomain-containing protein]] | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Bowkett | [[Category: Bountra C]] | ||
[[Category: Bradley | [[Category: Bowkett D]] | ||
[[Category: Brandao-Neto | [[Category: Bradley A]] | ||
[[Category: Brennan | [[Category: Brandao-Neto J]] | ||
[[Category: Burgess-Brown | [[Category: Brennan P]] | ||
[[Category: Collins | [[Category: Burgess-Brown N]] | ||
[[Category: Cox | [[Category: Collins P]] | ||
[[Category: Cox O]] | |||
[[Category: Douangamath | [[Category: Douangamath A]] | ||
[[Category: Edwards | [[Category: Edwards E]] | ||
[[Category: Fairhead | [[Category: Fairhead M]] | ||
[[Category: Krojer | [[Category: Krojer T]] | ||
[[Category: Ng | [[Category: Ng JT]] | ||
[[Category: Pearce | [[Category: Pearce NM]] | ||
[[Category: Strain-Damerell | [[Category: Strain-Damerell C]] | ||
[[Category: Talon | [[Category: Talon R]] | ||
[[Category: Wright | [[Category: Wright N]] | ||
[[Category: | [[Category: Von Delft F]] | ||
