5an4: Difference between revisions

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<StructureSection load='5an4' size='340' side='right'caption='[[5an4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5an4' size='340' side='right'caption='[[5an4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5an4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AN4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5an4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AN4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5amw|5amw]], [[5amx|5amx]], [[5amy|5amy]], [[5amz|5amz]], [[5an2|5an2]], [[5and|5and]], [[5ane|5ane]], [[5ang|5ang]], [[5ani|5ani]], [[5anj|5anj]], [[5ank|5ank]], [[5anl|5anl]], [[5ano|5ano]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5an4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5an4 OCA], [https://pdbe.org/5an4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5an4 RCSB], [https://www.ebi.ac.uk/pdbsum/5an4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5an4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5an4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5an4 OCA], [http://pdbe.org/5an4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5an4 RCSB], [http://www.ebi.ac.uk/pdbsum/5an4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5an4 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN]] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.  
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN]] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.  
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cipriani, F]]
[[Category: Cipriani F]]
[[Category: Cornaciu, I]]
[[Category: Cornaciu I]]
[[Category: Dalhus, B]]
[[Category: Dalhus B]]
[[Category: Hoffmann, G]]
[[Category: Hoffmann G]]
[[Category: Marquez, J A]]
[[Category: Marquez JA]]
[[Category: Ytre-Arne, M]]
[[Category: Ytre-Arne M]]
[[Category: Zander, U]]
[[Category: Zander U]]
[[Category: Allergen]]
[[Category: Automated cryo-cooling]]
[[Category: Automated crystal harvesting]]
[[Category: Bet v 1]]
[[Category: Crystaldirect]]
[[Category: Flavonoid]]
[[Category: Hydrolase]]
[[Category: Pyr/pyl/rcar]]
Retrieved from "https://proteopedia.org/5an4"