5anl: Difference between revisions

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<StructureSection load='5anl' size='340' side='right'caption='[[5anl]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5anl' size='340' side='right'caption='[[5anl]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5anl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ANL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ANL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5anl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ANL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ANL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBQ:(8S)-2-(MORPHOLIN-4-YL)-9-[2-(PROPAN-2-YLOXY)ETHYL]-8-(TRIFLUOROMETHYL)-6,7,8,9-TETRAHYDRO-4H-PYRIMIDO[1,2-A]PYRIMIDIN-4-ONE'>RBQ</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RBQ:(8S)-2-(MORPHOLIN-4-YL)-9-[2-(PROPAN-2-YLOXY)ETHYL]-8-(TRIFLUOROMETHYL)-6,7,8,9-TETRAHYDRO-4H-PYRIMIDO[1,2-A]PYRIMIDIN-4-ONE'>RBQ</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5amw|5amw]], [[5amx|5amx]], [[5amy|5amy]], [[5amz|5amz]], [[5an2|5an2]], [[5an4|5an4]], [[5and|5and]], [[5ane|5ane]], [[5ang|5ang]], [[5ani|5ani]], [[5anj|5anj]], [[5ank|5ank]], [[5ano|5ano]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5anl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5anl OCA], [https://pdbe.org/5anl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5anl RCSB], [https://www.ebi.ac.uk/pdbsum/5anl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5anl ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5anl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5anl OCA], [http://pdbe.org/5anl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5anl RCSB], [http://www.ebi.ac.uk/pdbsum/5anl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5anl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphatidylinositol 3-kinase]]
[[Category: Cipriani F]]
[[Category: Cipriani, F]]
[[Category: Cornaciu I]]
[[Category: Cornaciu, I]]
[[Category: Hoffmann G]]
[[Category: Hoffmann, G]]
[[Category: Marquette J-P]]
[[Category: Marquette, J P]]
[[Category: Marquez JA]]
[[Category: Marquez, J A]]
[[Category: Mathieu M]]
[[Category: Mathieu, M]]
[[Category: Zander U]]
[[Category: Zander, U]]
[[Category: Automated cryo- cooling]]
[[Category: Automated crystal harvesting]]
[[Category: Crystaldirect]]
[[Category: Lipid kinase]]
[[Category: Transferase]]
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