5ans: Difference between revisions

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<StructureSection load='5ans' size='340' side='right'caption='[[5ans]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5ans' size='340' side='right'caption='[[5ans]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ans]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ANS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ANS FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ans]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ANS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ANS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RX8:1-[4-AMINO-2-(ETHOXYMETHYL)-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL]-2-METHYLPROPAN-2-OL'>RX8</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RX8:1-[4-AMINO-2-(ETHOXYMETHYL)-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL]-2-METHYLPROPAN-2-OL'>RX8</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5anm|5anm]], [[5ant|5ant]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ans FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ans OCA], [https://pdbe.org/5ans PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ans RCSB], [https://www.ebi.ac.uk/pdbsum/5ans PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ans ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/8-oxo-dGTP_diphosphatase 8-oxo-dGTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.55 3.6.1.55] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ans FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ans OCA], [http://pdbe.org/5ans PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ans RCSB], [http://www.ebi.ac.uk/pdbsum/5ans PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ans ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 8-oxo-dGTP diphosphatase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Alwan, H]]
[[Category: Alwan H]]
[[Category: Bista, M]]
[[Category: Bista M]]
[[Category: Breed, J]]
[[Category: Breed J]]
[[Category: Eckersley, K]]
[[Category: Eckersley K]]
[[Category: Fillery, S]]
[[Category: Fillery S]]
[[Category: Foote, K M]]
[[Category: Foote KM]]
[[Category: Goodwin, L]]
[[Category: Goodwin L]]
[[Category: Jones, D]]
[[Category: Jones D]]
[[Category: Kack, H]]
[[Category: Kack H]]
[[Category: Kettle, J G]]
[[Category: Kettle JG]]
[[Category: Lau, A]]
[[Category: Lau A]]
[[Category: Nissink, J W.M]]
[[Category: Nissink JWM]]
[[Category: Read, J]]
[[Category: Read J]]
[[Category: Scott, J]]
[[Category: Scott J]]
[[Category: Taylor, B]]
[[Category: Taylor B]]
[[Category: Walker, G]]
[[Category: Walker G]]
[[Category: Wissler, L]]
[[Category: Wissler L]]
[[Category: Hydrolase]]
[[Category: Inhibition]]
[[Category: Mth1]]
[[Category: Nucleotide hydrolysis]]
[[Category: Oncology]]
Retrieved from "https://proteopedia.org/5ans"