5aod: Difference between revisions

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<StructureSection load='5aod' size='340' side='right'caption='[[5aod]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5aod' size='340' side='right'caption='[[5aod]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5aod]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5aod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AOD FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aoe|5aoe]], [[5aof|5aof]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aod OCA], [https://pdbe.org/5aod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aod RCSB], [https://www.ebi.ac.uk/pdbsum/5aod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aod ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aod OCA], [http://pdbe.org/5aod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aod RCSB], [http://www.ebi.ac.uk/pdbsum/5aod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aod ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).  
[https://www.uniprot.org/uniprot/TACY_STRR6 TACY_STRR6] A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.[UniProtKB:P13128]


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pee, K van]]
[[Category: Streptococcus pneumoniae]]
[[Category: Yildiz, O]]
[[Category: Yildiz O]]
[[Category: Cholesterol dependent cytolysin]]
[[Category: Van Pee K]]
[[Category: Pore forming toxin]]
[[Category: Toxin]]
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