5arf: Difference between revisions

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<StructureSection load='5arf' size='340' side='right'caption='[[5arf]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
<StructureSection load='5arf' size='340' side='right'caption='[[5arf]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5arf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ARF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ARF FirstGlance]. <br>
<table><tr><td colspan='2'>[[5arf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ARF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ARF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I9H:N-[3-(4-CHLOROPHENYL)-1-{N-CYANO-N-[3-(DIFLUOROMETHOXY)PHENYL]CARBAMIMIDOYL}-4,5-DIHYDRO-1H-+PYRAZOL-4-YL]-N-ETHYL-2-HYDROXYACETAMIDE'>I9H</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I9H:N-[3-(4-CHLOROPHENYL)-1-{N-CYANO-N-[3-(DIFLUOROMETHOXY)PHENYL]CARBAMIMIDOYL}-4,5-DIHYDRO-1H-+PYRAZOL-4-YL]-N-ETHYL-2-HYDROXYACETAMIDE'>I9H</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5arf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5arf OCA], [http://pdbe.org/5arf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5arf RCSB], [http://www.ebi.ac.uk/pdbsum/5arf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5arf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5arf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5arf OCA], [https://pdbe.org/5arf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5arf RCSB], [https://www.ebi.ac.uk/pdbsum/5arf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5arf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Histone methyltransferase|Histone methyltransferase]]
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Badock, V]]
[[Category: Badock V]]
[[Category: Barak, N]]
[[Category: Barak N]]
[[Category: Brumby, T]]
[[Category: Brumby T]]
[[Category: Christ, C D]]
[[Category: Christ CD]]
[[Category: Eggert, E]]
[[Category: Eggert E]]
[[Category: Fernandez-Montalvan, A E]]
[[Category: Fernandez-Montalvan AE]]
[[Category: Hartung, I V]]
[[Category: Hartung IV]]
[[Category: Hillig, R C]]
[[Category: Hillig RC]]
[[Category: Koehr, S]]
[[Category: Koehr S]]
[[Category: Laak, A ter]]
[[Category: Mowat J]]
[[Category: Mowat, J]]
[[Category: Mueller T]]
[[Category: Mueller, T]]
[[Category: Stellfeld T]]
[[Category: Stellfeld, T]]
[[Category: Stoeckigt D]]
[[Category: Stoeckigt, D]]
[[Category: Stresemann C]]
[[Category: Stresemann, C]]
[[Category: Weinmann H]]
[[Category: Weinmann, H]]
[[Category: Weiske J]]
[[Category: Weiske, J]]
[[Category: Ter Laak A]]
[[Category: Drug target]]
[[Category: Methyltransferase]]
[[Category: Set domain]]
[[Category: Sgc probe]]
[[Category: Small molecule inhibitor]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5arf"