5b8a: Difference between revisions

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<StructureSection load='5b8a' size='340' side='right'caption='[[5b8a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5b8a' size='340' side='right'caption='[[5b8a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5b8a]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B8A FirstGlance]. <br>
<table><tr><td colspan='2'>[[5b8a]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B8A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5b8b|5b8b]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b8a OCA], [https://pdbe.org/5b8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b8a RCSB], [https://www.ebi.ac.uk/pdbsum/5b8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b8a ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDX2, NKEFB, TDPX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b8a OCA], [http://pdbe.org/5b8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b8a RCSB], [http://www.ebi.ac.uk/pdbsum/5b8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b8a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AHPC_ECOLI AHPC_ECOLI]] Directly reduces organic hydroperoxides in its reduced dithiol form.  
[https://www.uniprot.org/uniprot/AHPC_ECOLI AHPC_ECOLI] Directly reduces organic hydroperoxides in its reduced dithiol form.[https://www.uniprot.org/uniprot/PRDX2_HUMAN PRDX2_HUMAN] Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Escherichia coli K-12]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Peroxiredoxin]]
[[Category: Eisenhaber B]]
[[Category: Eisenhaber, B]]
[[Category: Eisenhaber F]]
[[Category: Eisenhaber, F]]
[[Category: Gruber G]]
[[Category: Gruber, G]]
[[Category: Kamariah N]]
[[Category: Kamariah, N]]
[[Category: Sek MF]]
[[Category: Sek, M F]]
[[Category: Ahpc]]
[[Category: Alkylhydroperoxide reductase]]
[[Category: Chimeric]]
[[Category: Oxidoreductase]]